HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Selective PDE inhibitors as novel treatments for respiratory diseases.

Abstract
Phosphodiesterases (PDEs) are a family of enzymes which catalyse the metabolism of the intracellular cyclic nucleotides, c-AMP and c-GMP that are expressed in a variety of cell types and in the context of respiratory diseases, It is now recognised that the use of PDE3, PDE4 and mixed PDE3/4 inhibitors can provide clinical benefit to patients with asthma or chronic obstructive pulmonary disease (COPD). The orally active PDE4 inhibitor Roflumilast-n-oxide has been approved for treatment of severe exacerbations of COPD as add-on therapy to standard drugs. This review discusses the involvement of PDEs in airway diseases and various strategies that are currently being pursued to improve efficacy and reduce side-effects of PDE4 inhibitors, including delivery via the inhaled route, mixed PDE inhibitors and/or antisense biologicals targeted towards PDE4.
AuthorsClive P Page, Domenico Spina
JournalCurrent opinion in pharmacology (Curr Opin Pharmacol) Vol. 12 Issue 3 Pg. 275-86 (Jun 2012) ISSN: 1471-4973 [Electronic] England
PMID22497841 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2012 Elsevier Ltd. All rights reserved.
Chemical References
  • Isoenzymes
  • Phosphodiesterase 3 Inhibitors
  • Phosphodiesterase 4 Inhibitors
  • Phosphodiesterase Inhibitors
  • Phosphoric Diester Hydrolases
Topics
  • Animals
  • Asthma (drug therapy, enzymology, metabolism)
  • Drug Therapy, Combination (adverse effects)
  • Humans
  • Isoenzymes (antagonists & inhibitors)
  • Molecular Targeted Therapy (adverse effects)
  • Phosphodiesterase 3 Inhibitors (adverse effects, pharmacology, therapeutic use)
  • Phosphodiesterase 4 Inhibitors (adverse effects, pharmacology, therapeutic use)
  • Phosphodiesterase Inhibitors (adverse effects, pharmacology, therapeutic use)
  • Phosphoric Diester Hydrolases (chemistry, metabolism)
  • Pulmonary Disease, Chronic Obstructive (drug therapy, enzymology, metabolism)
  • Respiratory System (drug effects, enzymology, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: