Abstract | OBJECTIVE: DESIGN, PARTICIPANTS AND SETTING: A cohort study (the Concord Health and Ageing in Men Project) involving a representative sample of 1434 eligible community-dwelling men with no diagnosis of prostate cancer who were aged 70 years and over and living in a defined geographic area in Sydney, with baseline data collected between 28 January 2005 and 4 June 2007. MAIN OUTCOME MEASURES: RESULTS: 11% of men (155) had a PSA level of ≥6.5 ng/mL, increasing from 7.5% of men aged 70-74 years to 31.4% of men aged≥90 years. PSA levels varied with ethnicity, with Australian-born men (695) having the highest levels (median, 2.3 ng/mL; 5th-95th percentile, 0.4-10.1 ng/mL), followed by men born in China (n=42; 2.1 ng/mL; 0.4-12.4 ng/mL), United Kingdom and Ireland (n=70; 1.9 ng/mL; 0.3-8.9 ng/mL), Greece (n=59; 1.5 ng/mL; 0.2-6.1 ng/mL), and Italy (n=293; 1.4 ng/mL; 0.3-7.2 ng/mL). A PSA test in the previous 2 years was reported by 48% of participants, and a digital rectal examination (DRE) in the previous 2 years by 37%. CONCLUSIONS: A significant number of men aged over 70 years reported recent prostate cancer tests. The PSA level ranges reported in this cohort will help with interpreting serum PSA level findings in men aged over 70 years.
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Authors | Melisa J Litchfield, Robert G Cumming, David P Smith, Vasi Naganathan, David G Le Couteur, Louise M Waite, Fiona M Blyth, David J Handelsman |
Journal | The Medical journal of Australia
(Med J Aust)
Vol. 196
Issue 6
Pg. 395-8
(Apr 02 2012)
ISSN: 1326-5377 [Electronic] Australia |
PMID | 22471541
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Prostate-Specific Antigen
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Topics |
- Age Factors
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(blood)
- Follow-Up Studies
- Humans
- Male
- New South Wales
(epidemiology)
- Prevalence
- Prognosis
- Prostate-Specific Antigen
(blood)
- Prostatic Neoplasms
(blood, diagnosis, epidemiology)
- Retrospective Studies
- Surveys and Questionnaires
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