Carbon ion radiotherapy for recurrent malignant transformation from mature cystic teratoma of the ovary.

Abstract

Mature cystic teratoma (MCT) is the most common tumor of the ovary; malignant transformation (MT) of squamous cell carcinoma is a rare disorder. A 78-year-old woman with stage IIc MT-MCT (squamous cell carcinoma [SCC]) underwent a total abdominal hysterectomy and bilateral salpingo-oophorectomy; there was residual tumor in the pelvis. The patient was treated with six courses of paclitaxel and carboplatin, but the recurrent tumor grew. The patient was then treated with carbon ion radiotherapy (CIRT). The recurrent tumor shrank and the patient has been free of clinical disease for 53 months. CIRT can be considered as a treatment for recurrent MT-MCT.

• Authors: Yumiko Ito, Shigehiko Morikawa, Shingo Kato, Hiroaki Kajiyama, Akihiko Nawa, Fumitaka Kikkawa
• Journal: The journal of obstetrics and gynaecology research (J Obstet Gynaecol Res) Vol. 38 Issue 5 Pg. 880-3 (May 2012) ISSN: 1447-0756 [Electronic] Australia
• PMID: 22449402 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2012 The Authors. Journal of Obstetrics and Gynaecology Research © 2012 Japan Society of Obstetrics and Gynecology.

Chemical References

• Antineoplastic Agents
• Carbon Radioisotopes
• Carboplatin
• Paclitaxel

Topics

• Aged
• Antineoplastic Agents (therapeutic use)
• Carbon Radioisotopes (therapeutic use)
• Carboplatin (therapeutic use)
• Cell Transformation, Neoplastic (pathology)
• Combined Modality Therapy
• Female
• Humans
• Neoplasm Recurrence, Local (drug therapy, pathology, radiotherapy, surgery)
• Ovarian Neoplasms (drug therapy, pathology, radiotherapy, surgery)
• Ovary (pathology, surgery)
• Paclitaxel (therapeutic use)
• Teratoma (drug therapy, pathology, radiotherapy, surgery)
• Treatment Outcome