Adrenomedullin and pregnancy: perspectives from animal models to humans.

Abstract

A healthy pregnancy requires strict coordination of genetic, physiologic and environmental factors. The relatively common incidence of infertility and pregnancy complications has resulted in increased interest in understanding the mechanisms that underlie normal versus abnormal pregnancy. The peptide hormone adrenomedullin (AM) has recently been the focus of some exciting breakthroughs in the pregnancy field. Supported by mechanistic studies in genetic animal models, there continues to be a growing body of evidence demonstrating the importance of AM protein levels in a variety of human pregnancy complications. With more extensive mechanistic studies and improved consistency in clinical measurements of AM, there is great potential for the development of AM as a clinically-relevant biomarker in pregnancy and pregnancy complications.

• Authors: Patricia M Lenhart, Kathleen M Caron
• Journal: Trends in endocrinology and metabolism: TEM (Trends Endocrinol Metab) Vol. 23 Issue 10 Pg. 524-32 (Oct 2012) ISSN: 1879-3061 [Electronic] United States
• PMID: 22425034 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Adrenomedullin
• Calcitonin Gene-Related Peptide

Topics

• Adrenomedullin (metabolism)
• Animals
• Calcitonin Gene-Related Peptide (metabolism)
• Female
• Fertility (physiology)
• Humans
• Models, Animal
• Pregnancy
• Pregnancy Complications (metabolism)