Abstract | PURPOSE: METHODS: RESULTS:
Cancer tissue specimens from 44.6% of patients had positive staining with MAM, which recognized α2,3sialylated type 2 chain (NeuAcα2,3Galβ1,4GlcNAcβR) structures, but normal colorectal mucosa showed only weak staining with MAM was observed. More lymph node metastases and lymphatic invasion were seen in patients with positive staining with MAM (P < 0.01), while not with other lectins or antibodies that recognized sialylated glycoconjugates or sialyl Lewis-related antigens. The five-year survival rate of patients with MAM-positive staining was significantly lower than that with MAM-negative staining when including T0-1 cases, but there was no difference in cases with T2-4. There was no difference in the patients' survival rates when the tissues were stained with MAA, SSA or PNA lectins. CONCLUSION: α2,3Sialylated type 2 chain structures were predominantly expressed in colorectal tissues associated with the malignant transformation, in particular, with lymphatic spread of distal colorectal adenocarcinomas.
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Authors | Takaharu Fukasawa, Takayuki Asao, Hayato Yamauchi, Munenori Ide, Yuichi Tabe, Takaaki Fujii, Satoru Yamaguchi, Soichi Tsutsumi, Shin Yazawa, Hiroyuki Kuwano |
Journal | Surgery today
(Surg Today)
Vol. 43
Issue 2
Pg. 155-62
(Feb 2013)
ISSN: 1436-2813 [Electronic] Japan |
PMID | 22398718
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Glycoconjugates
- Plant Lectins
- Sialic Acids
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Topics |
- Adenocarcinoma
(metabolism, mortality, pathology, surgery)
- Biomarkers, Tumor
(chemistry, metabolism)
- Cell Transformation, Neoplastic
(chemistry, metabolism, pathology)
- Colectomy
- Colorectal Neoplasms
(metabolism, mortality, pathology, surgery)
- Female
- Glycoconjugates
(chemistry, metabolism)
- Humans
- Immunohistochemistry
- Kaplan-Meier Estimate
- Lymphatic Metastasis
- Male
- Plant Lectins
- Rectum
(surgery)
- Sialic Acids
(chemistry, metabolism)
- Survival Rate
- Treatment Outcome
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