Atherosclerosis in chronic kidney disease: lessons learned from glycation in diabetes.

Abstract

In diabetes, glycation is a nonenzymatic posttranslational modification resulting from the bonding of a sugar molecule with a protein or lipid followed by oxidation, resulting in the development of advanced glycation end products (AGE). Like glycation, carbamylation is a posttranslational protein modification that is associated with AGE formation. Glycation of extracellular matrix proteins and low-density lipoprotein with subsequent deposition in the vessel wall could contribute to inflammatory response and atheroma formation. It is logical to extrapolate that carbamylation may result in modification of vessel wall proteins similar to glycation, and predispose to atherosclerosis.

• Authors: Dilbahar S Mohar, Ailin Barseghian, Nezam Haider, Michael Domanski, Jagat Narula
• Journal: The Medical clinics of North America (Med Clin North Am) Vol. 96 Issue 1 Pg. 57-65 (Jan 2012) ISSN: 1557-9859 [Electronic] United States
• PMID: 22391251 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Glycation End Products, Advanced
• Inflammation Mediators
• Lipoproteins, LDL

Topics

• Atherosclerosis (complications, metabolism)
• Carbohydrate Metabolism
• Chronic Disease
• Diabetes Complications (metabolism)
• Fluorescent Antibody Technique
• Glycation End Products, Advanced (metabolism)
• Humans
• Inflammation Mediators (metabolism)
• Kidney Diseases (complications, metabolism)
• Lipid Metabolism
• Lipoproteins, LDL (metabolism)
• Oxidation-Reduction
• Plaque, Atherosclerotic (complications, metabolism)
• Risk Factors
• Tunica Intima (metabolism)