Argatroban therapy for heparin-induced thrombocytopenia during pregnancy in a woman with hereditary antithrombin deficiency.

Abstract

A 33-year-old woman developed deep venous thrombosis at 7 gestational weeks (GW). Heparin-induced thrombocytopenia was evident at 9 GW during unfractionated heparin infusion. Immediately, anticoagulation therapies together with antithrombin (AT) infusion were commenced with the use of argatroban from 9 GW, and fondaparinux was substituted for argatroban after 24 GW. The patient had hereditary AT deficiency type I determined by laboratory findings and results of genomic DNA analysis. The pregnancy ended in full-term vaginal delivery of a healthy male without adverse effects of the anticoagulation therapies. This was the first report of a pregnant woman who developed heparin-induced thrombocytopenia caused by heparin therapy for deep venous thrombosis due to AT deficiency.

• Authors: Kenji Tanimura, Yashuhiko Ebina, Ayako Sonoyama, Hiroki Morita, Shigeki Miyata, Hideto Yamada
• Journal: The journal of obstetrics and gynaecology research (J Obstet Gynaecol Res) Vol. 38 Issue 4 Pg. 749-52 (Apr 2012) ISSN: 1447-0756 [Electronic] Australia
• PMID: 22380425 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2012 The Authors. Journal of Obstetrics and Gynaecology Research © 2012 Japan Society of Obstetrics and Gynecology.

Chemical References

• Anticoagulants
• Antithrombins
• Pipecolic Acids
• Sulfonamides
• Heparin
• Arginine
• argatroban

Topics

• Adult
• Anticoagulants (adverse effects)
• Antithrombins (analysis)
• Arginine (analogs & derivatives)
• Blood Coagulation Disorders, Inherited (complications)
• Female
• Heparin (adverse effects)
• Humans
• Male
• Pipecolic Acids (therapeutic use)
• Pregnancy
• Pregnancy Complications, Hematologic (drug therapy)
• Sulfonamides
• Thrombocytopenia (chemically induced, drug therapy)
• Venous Thrombosis (drug therapy)