Abstract |
Programmed cell death 1 (PDCD-1) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) both negatively regulate the T-cell response in chronic hepatitis B virus (HBV) infection. This study determined genotypes of PDCD1 -606 G/A and +8669 G/A and CTLA4 -318 C/T and +49 A/G polymorphisms in 172 chronic HBV patients and 145 healthy controls and analyzed the interaction between these polymorphisms of the 2 genes. The results indicated that carriage of the PDCD1 +8669 A allele was increased in HBV patients carrying the CTLA4 -318 CC genotype and carrying the CTLA4 +49 AA genotype compared with controls carrying the CTLA4 -318 CC genotype (80.2% vs 64.8%, p = 0.002, odds ratio [OR] = 2.202, 95% confidence interval [95% CI] = 1.326-3.656) and carrying the CTLA4 +49 AA genotype (18.6% vs 9.7%, p = 0.024, OR = 2.139, 95% CI = 1.093-4.187), respectively. More obviously, carriage of the PDCD1 +8669 AA genotype was significantly increased in HBV patients carrying the CTLA4 +49 AA genotype compared with controls carrying the same CTLA4 +49 genotype (14.0% vs 3.4%, p = 0.001, OR = 4.541, 95% CI = 1.686-12.230). These results suggest that the PDCD1 +8669 A allele and AA genotype may amplify the predisposing effect conferred by the CTLA4 polymorphism through PDCD1 and CTLA4 gene interaction in chronic HBV infection.
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Authors | Guoyu Zhang, Qunying Han, Shaoqiong Duan, Zhu Li, Na Li, Qianqian Zhu, Jinghong Chen, Yi Lv, Xiaoyan Zeng, Yanping Chen, Zhengwen Liu |
Journal | Human immunology
(Hum Immunol)
Vol. 73
Issue 4
Pg. 421-5
(Apr 2012)
ISSN: 1879-1166 [Electronic] United States |
PMID | 22342451
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- CTLA-4 Antigen
- Programmed Cell Death 1 Receptor
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Topics |
- Adult
- Alleles
- CTLA-4 Antigen
(genetics)
- Epistasis, Genetic
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Hepatitis B, Chronic
(genetics)
- Humans
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Programmed Cell Death 1 Receptor
(genetics)
- Young Adult
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