[Distributional characteristics of apolipoprotein A5 Gene c.553G > T polymorphism and association with serum triglyceride in healthy Chinese Han and Uighur people].

Abstract

OBJECTIVE:

To explore the distribution characteristics of apolipoprotein A5 (ApoA5) gene c.553G > T polymorphism and the relationship of serum lipid in Chinese Han and Uighur populations in Xinjiang, China.

METHODS:

The genotypes of ApoA5 gene c.553G > T polymorphism were detected in 406 Uighur and 527 Han people by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP).

RESULTS:

The frequencies of GG, GT and TT genotypes of ApoA5 gene c.553G > T were 378 (93.1%), 27 (6.7%) and 1 (0.25%) patients in Uighurs versus 478 (90.7%) patients, 49 (9.3%) patients and 0% in Hans. There was no significant difference in the distribution of genotypes between two groups (P > 0.05). In both groups, individuals with T allele (TT + GT genotype) had a higher level of serum triglyceride than those with GG genotype. After adjusting for gender, age, smoking, alcoholism, body mass index, blood pressure and blood lipid, non-conditional logistic regression analyses revealed that individuals with T allele (TT + GT genotype) in both groups had an elevated risk of HTG versus the GG genotype (OR = 3.31, 95%CI: 1.31 - 8.36 in Uighurs vs OR = 3.98, 95%CI: 1.81 - 8.74 in Hans).

CONCLUSION:

The mutation of c.553G > T polymorphism of ApoA5 gene is associated with the level of serum triglyceride in Uighur and Han populations of Xinjiang. And T allele may be a risk factor of hypertriglyceridemia.

• Authors: Anniwaer Abulizi, Shan Yuan, Yi-tong Ma, Xiang Xie, Yi-ning Yang, Zhen-yan Fu, Xiang Ma, Xiao-mei Li, Fen Liu, Bang-dang Chen
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 91 Issue 40 Pg. 2837-40 (Nov 01 2011) ISSN: 0376-2491 [Print] China
• PMID: 22333545 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• APOA5 protein, human
• Apolipoprotein A-V
• Apolipoproteins A
• Triglycerides

Topics

• Adult
• Aged
• Alleles
• Apolipoprotein A-V
• Apolipoproteins A (genetics)
• Asian People (genetics)
• China
• Female
• Gene Frequency
• Genotype
• Humans
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Triglycerides (blood)