Abstract | PURPOSE: To determine the incidence, clinical features, and outcomes of infectious endophthalmitis after Boston Type 1 Keratoprosthesis (KPro) implantation. METHODS: Retrospective, consecutive case series. Chart review of 105 patients (126 eyes) who had KPro implantation at Cincinnati Eye Institute between November 2004 and November 2010 and who were followed up for at least 1 month (range, 1 month to 66 months; mean 25 months) revealed 3 cases who developed infectious endophthalmitis. RESULTS: CONCLUSIONS:
Infectious endophthalmitis is a devastating complication that can occur after Boston KPro implantation even with prophylactic vancomycin, a fourth-generation fluoroquinolone, and a therapeutic contact lens. Fungal and gram-negative organisms are a growing cause for concern. Further study is needed on optimal prophylaxis regimens, including the use of antifungals, especially for high-risk eyes, such as those with autoimmune cicatrizing disease.
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Authors | Clara C Chan, Edward J Holland |
Journal | Cornea
(Cornea)
Vol. 31
Issue 4
Pg. 346-9
(Apr 2012)
ISSN: 1536-4798 [Electronic] United States |
PMID | 22314825
(Publication Type: Journal Article)
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Chemical References |
- Vancomycin
- Amphotericin B
- Ceftazidime
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Topics |
- Administration, Oral
- Aged
- Amphotericin B
(administration & dosage)
- Artificial Organs
- Candida albicans
(isolation & purification)
- Candidiasis
(diagnosis, drug therapy, microbiology)
- Ceftazidime
(administration & dosage)
- Cornea
- Drug Therapy, Combination
- Endophthalmitis
(diagnosis, drug therapy, microbiology)
- Eye Infections, Bacterial
(diagnosis, drug therapy, microbiology)
- Eye Infections, Fungal
(diagnosis, drug therapy, microbiology)
- Female
- Graft Rejection
(surgery)
- Gram-Negative Bacterial Infections
(diagnosis, drug therapy, microbiology)
- Humans
- Incidence
- Intravitreal Injections
- Middle Aged
- Ochrobactrum anthropi
(isolation & purification)
- Postoperative Complications
- Prostheses and Implants
- Prosthesis Implantation
- Reoperation
- Retrospective Studies
- Vancomycin
(administration & dosage)
- Vitreous Body
(microbiology)
- Young Adult
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