Abstract | OBJECTIVE AND DESIGN: METHODS: HIV-PI effects were evaluated by cell invasion, growth or toxicity assays, and by RNA, protein or zymogram analyses. RESULTS: Both SQV and RTV inhibited CIN cell invasion, and this was paralleled by a reduced expression and proteolytic activity of the matrix metalloproteinase (MMP)-2 and 9 in treated cells. SQV and RTV also reduced CIN cell growth rate, but did not affect the invasion or growth of cells derived from highly progressed cervical carcinoma. CONCLUSION: As MMP-2 and MMP-9 have a key role in CIN evolution into cervical carcinoma, these results support the use of SQV or RTV for the block of CIN clinical progression in either HIV-infected or uninfected patients.
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Authors | Giovanni Barillari, André Iovane, Ilaria Bacigalupo, Clelia Palladino, Stefania Bellino, Patrizia Leone, Paolo Monini, Barbara Ensoli |
Journal | AIDS (London, England)
(AIDS)
Vol. 26
Issue 8
Pg. 909-19
(May 15 2012)
ISSN: 1473-5571 [Electronic] England |
PMID | 22313963
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- HIV Protease Inhibitors
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
- Saquinavir
- Ritonavir
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Topics |
- Epithelial Cells
(drug effects)
- Female
- HIV Protease Inhibitors
(pharmacology)
- Humans
- Matrix Metalloproteinase 2
(drug effects, metabolism)
- Matrix Metalloproteinase 9
(drug effects, metabolism)
- Ritonavir
(pharmacology)
- Saquinavir
(pharmacology)
- Uterine Cervical Neoplasms
(drug therapy)
- Uterine Cervical Dysplasia
(drug therapy)
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