Pilot study: alteration of deleted in liver cancer1 and phosphorylated focal adhesion kinase Y397 cytoplasmic expression and the prognostic value in advanced epithelial ovarian carcinoma.

Abstract

BACKGROUND:

Deletion in liver cancer gene (DLC1) and phosphorylated focal adhesion kinase (p-FAK) have recently been reported as metastasis-related genes. However, the roles and prognostic values of their expression in epithelial ovarian carcinomas (EOCs) remain unclear.

METHODS:

The expression and prognostic value of DLC1 and p-FAK Y397 in EOC were evaluated by immunohistochemistry and multivariate analysis.

RESULTS:

Low expression of DLC1 and high expression of p-FAK Y397 were found in the 76 cases of EOC. The expression of DLC1 and p-FAK Y397 were negatively correlated. Multivariate analysis showed that the combination of them was an independent prognostic marker of EOC (P = 0.0319).

CONCLUSIONS:

DLC1 and pFAK Y397 had an association with the clinicopathologic characteristics of EOC. Expression of neither of these genes was a prognostic factor alone, but the combination revealed a significant prognostic value in the 60 cases of advanced stage EOC.

• Authors: Dong-Mei Fan, Hui-Rong Shi
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 12 Issue 12 Pg. 8489-501 ( 2011) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 22272086 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• DLC1 protein, human
• GTPase-Activating Proteins
• Tumor Suppressor Proteins
• Focal Adhesion Kinase 1
• PTK2 protein, human

Topics

• Adult
• Aged
• Biomarkers, Tumor (genetics, metabolism)
• Carcinoma (diagnosis, metabolism)
• Case-Control Studies
• Female
• Focal Adhesion Kinase 1 (genetics, metabolism)
• GTPase-Activating Proteins (genetics, metabolism)
• Humans
• Middle Aged
• Ovarian Neoplasms (diagnosis, metabolism)
• Phosphorylation
• Pilot Projects
• Prognosis
• Tumor Suppressor Proteins (genetics, metabolism)