Abstract | BACKGROUND:
Aspirin, nonaspirin nonsteroidal anti-inflammatory drugs (NA- NSAIDs) and acetaminophen all have biologic effects that might reduce the risk of ovarian cancer. However, epidemiologic data on this question are mixed. METHODS: A population-based, case-control study in western Pennsylvania, eastern Ohio, and western New York State included 902 women with incident epithelial ovarian cancer who were diagnosed between February 2003 and November 2008 as well as 1802 matched controls. Regular use (at least 2 tablets per week for 6 months or more) of aspirin, NA- NSAIDs, and acetaminophen before the reference date (9 months before interview date) was assessed by in-person interview. We used logistic regression to calculate adjusted odds ratios ( ORs) and 95% confidence intervals (CIs). RESULTS: CONCLUSIONS:
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Authors | Wei-Hsuan Lo-Ciganic, Janice C Zgibor, Clareann H Bunker, Kirsten B Moysich, Robert P Edwards, Roberta B Ness |
Journal | Epidemiology (Cambridge, Mass.)
(Epidemiology)
Vol. 23
Issue 2
Pg. 311-9
(Mar 2012)
ISSN: 1531-5487 [Electronic] United States |
PMID | 22252409
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Acetaminophen
- Aspirin
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Topics |
- Acetaminophen
(pharmacology)
- Anti-Inflammatory Agents, Non-Steroidal
(pharmacology)
- Aspirin
(pharmacology)
- Case-Control Studies
- Chi-Square Distribution
- Dose-Response Relationship, Drug
- Female
- Humans
- Logistic Models
- Middle Aged
- New York
(epidemiology)
- Odds Ratio
- Ohio
(epidemiology)
- Ovarian Neoplasms
(epidemiology, prevention & control)
- Pennsylvania
(epidemiology)
- Risk Factors
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