[Interaction between the dexamethasone-receptor complex and Zajdela ascites hepatoma DNA].

Abstract

The activated dexamethasone--receptor complex from rat liver cell cytoplasm and from Zajdela ascite hepatoma cell cytoplasm is bound to Sepharose-immobilized native DNA containing different numbers of recurrent sequences. The DNA-bound hormonereceptor complex is eluted as three peaks by varying concentrations of NaCl. The binding in independent of the number of DNA recurrent sequences and of the source of the cytoplasmic complex used.

• Authors: M A Krasil'nikov, V V Adler
• Journal: Biokhimiia (Moscow, Russia) (Biokhimiia) Vol. 44 Issue 5 Pg. 917-22 (May 1979) ISSN: 0320-9725 [Print] Russia (Federation)
• Vernacular Title: Vzaimodeĭstvie kompleksa deksametazon-retseptor a DNK astsitnoĭ gepatomy Zaĭdelia.
• PMID: 222358 (Publication Type: English Abstract, Journal Article)

Chemical References

• DNA, Neoplasm
• Receptors, Cell Surface
• Receptors, Glucocorticoid
• Receptors, Steroid
• Dexamethasone

Topics

• Animals
• Base Sequence
• DNA, Neoplasm (metabolism)
• Dexamethasone (metabolism)
• Liver Neoplasms, Experimental (metabolism)
• Protein Binding
• Rats
• Receptors, Cell Surface (isolation & purification)
• Receptors, Glucocorticoid (metabolism)
• Receptors, Steroid (metabolism)