[A case of locally advanced gastric cancer responding to preoperative S-1/CDDP combination chemotherapy].

Abstract

A 59-year-old man visited our department with the complaint of an abdominal mass. After detailed examination, he was diagnosed with cT3 (SE) N2M0, cStage III C gastric cancer and underwent a 3 course preoperative S-1/CDDP combination chemotherapy. After tumor down-staging was achieved after the 3 course combination chemotherapy, a surgery was scheduled. The patient underwent distal gastrectomy with D2 lymph node dissection. Histopathological diagnosis was M, type 1, 75 × 35 mm, papillary>moderately-differentiated tubular adenocarcinoma [pT2 (MP), ly3, v0, pN2, Stage IIB]. The patient is now treated with oral S-1 as postoperative adjuvant chemotherapy on an outpatient basis, and there are no signs of recurrence as of 1 year after the surgery. Preoperative chemotherapy appears to be a promising treatment option for gastric cancer with extensive lymph node metastasis.

• Authors: Eriko Katsuta, Jun Kaneko, Noriko Iwata, Haruhiko Aoyagi, Tsuyoshi Yoshida, Taro Takahata, Kumi Hasegawa, Shizuaki Maejima
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 38 Issue 12 Pg. 2334-5 (Nov 2011) ISSN: 0385-0684 [Print] Japan
• PMID: 22202373 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Drug Combinations
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Cisplatin

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cisplatin (administration & dosage, therapeutic use)
• Combined Modality Therapy
• Drug Combinations
• Gastrectomy
• Humans
• Lymph Node Excision
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasm Staging
• Oxonic Acid (administration & dosage, therapeutic use)
• Stomach Neoplasms (drug therapy, pathology)
• Tegafur (administration & dosage, therapeutic use)
• Tomography, X-Ray Computed