[A case of advanced gastric cancer with splenic vein thrombus successfully treated with S-1 plus CPT-11 neoadjuvant chemotherapy].

Abstract

A 63-year-old male admitted for hematemesis was diagnosed with type 3 advanced gastric cancer located in the upper and middle body of the stomach in an endoscopic examination. Abdominal computed tomography demonstrated lymph nodes metastasis and a splenic vein thrombus. Since curative resection was not deemed possible, we performed neoadjuvant chemotherapy using S-1 (120 mg, day 1-21) plus CPT-11 (135 mg, day 1 and 15) except for down-staging. After 4 courses of chemotherapy, gastric tumor and metastatic lymph nodes were reduced in size and the splenic vein thrombus was disappeared, and then total gastrectomy was performed (tub2, T2 (MP) N0 H0 M0 P0 CY0, Stage IB). S-1 medication was applied as adjuvant chemotherapy. Forty months passed from the operation, the patient remains alive with no signs of relapse.

• Authors: Hirokazu Taniguchi, Yutaka Kimura, Chiwan Kim, Katsuki Danno, Naofumi Kagara, Toshiyuki Kanoh, Tadashi Ohnishi, Takeshi Tohno, Yoshiaki Nakano, Takushi Monden, Shingi Imaoka
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 38 Issue 12 Pg. 1954-6 (Nov 2011) ISSN: 0385-0684 [Print] Japan
• PMID: 22202250 (Publication Type: Case Reports, Journal Article)

Chemical References

• Drug Combinations
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Irinotecan
• Camptothecin

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Camptothecin (administration & dosage, analogs & derivatives, therapeutic use)
• Drug Combinations
• Humans
• Irinotecan
• Male
• Middle Aged
• Neoadjuvant Therapy
• Neoplasm Staging
• Oxonic Acid (administration & dosage, therapeutic use)
• Remission Induction
• Splenic Vein (pathology)
• Stomach Neoplasms (complications, drug therapy, pathology, surgery)
• Tegafur (administration & dosage, therapeutic use)
• Tomography, X-Ray Computed
• Venous Thrombosis (etiology)