Curcumin: the multi-targeted therapy for cancer regression.
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| Abstract |
Tumors are multifaceted; in fact, numerous things happen in synchrony to enable tumor promotion and progression. Any type of cancer is associated with the modification of 300-500 normal genes and characterized by the deregulation of cell signaling pathways at multiple steps leading to cancer phenotype. Thus a proper management of tumorigenesis requires the development of multi-targeted therapies. Several adverse effects associated with present day cancer therapies and the thirsts for multi-targeted safe anticancer drug instigate the use of natural polyphenol, curcumin. It appears to involve a blend of anti-carcinogenic, pro-apoptotic, anti-angiogenic, anti-metastatic, immunomodulatory and antioxidant activities. Also the molecular mechanisms implicated for the pleotropic activities of curcumin are diverse and seem to involve a combination of cell signaling pathways at multiple levels of tumorigenesis. Being a potent scavenger of reactive oxygen species, curcumin also ameliorates systemic toxicity in tumor-bearer. Taken together, by placing particular emphasis on molecular basis of tumor promotion and progression this review summarizes the anti-cancer properties of curcumin that may be exploited for successful clinical cancer prevention.
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| Authors | Dewan Md Sakib Hossain, Sankar Bhattacharyya, Tanya Das, Gaurisankar Sa |
| Journal | Frontiers in bioscience (Scholar edition) (Front Biosci (Schol Ed)) Vol. 4 Issue 1 Pg. 335-55 (01 01 2012) ISSN: 1945-0524 [Electronic] Singapore |
| PMID | 22202064 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review) |
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