Treatment of primary aspergilloma of the central nervous system in a diabetic immunocompetent patient with surgical resection and voriconazole: a case report and review of the literature.

Abstract

Fungal infections of the central nervous system (CNS) are uncommon and occur mainly in immunocompromised patients. We describe a case of central nervous system aspergilloma without any evidence of systemic or paranasal foci in a diabetic but otherwise immunocompetent 71-year-old female treated successfully with surgical resection and medical therapy with voriconazole. Magnetic resonance imaging (MRI) after 6 months of voriconazole showed improvement and no evidence of residual or recurrent disease. Given its good CNS penetration, voriconazole along with surgical resection appears to be promising in treatment of these infections. Our case also demonstrates the importance of surgical intervention in the diagnosis and management of these atypical cases.

• Authors: Robin Koshy, Prashant Malhotra
• Journal: Turkish neurosurgery (Turk Neurosurg) Vol. 21 Issue 4 Pg. 641-4 ( 2011) ISSN: 1019-5149 [Print] Turkey
• PMID: 22194129 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Antifungal Agents
• Pyrimidines
• Triazoles
• Voriconazole

Topics

• Aged
• Antifungal Agents (administration & dosage)
• Diabetes Complications (microbiology, pathology, surgery)
• Diabetes Mellitus, Type 2 (complications)
• Female
• Humans
• Immunocompetence (physiology)
• Neuroaspergillosis (drug therapy, pathology, surgery)
• Neurosurgical Procedures (methods)
• Pyrimidines (administration & dosage)
• Temporal Lobe (microbiology, pathology, surgery)
• Treatment Outcome
• Triazoles (administration & dosage)
• Voriconazole