Triple-negative subtype predicts poor overall survival and high locoregional relapse in inflammatory breast cancer.
Abstract | BACKGROUND: METHODS: We retrospectively analyzed the records of 316 women who presented to MD Anderson Cancer Center in 1989-2008 with newly diagnosed IBC without distant metastases. Most patients received neoadjuvant chemotherapy, mastectomy, and postmastectomy radiation. Patients were grouped according to receptor status: ER(+) (ER(+)/PR(+) and HER-2-; n = 105), ER(+)HER-2(+) (ER(+)/PR(+) and HER-2(+); n = 37), HER-2(+) (ER(-)/PR(-) and HER-2(+); n = 83), or triple-negative (TN) (ER(-)PR(-)HER-2(-); n = 91). Kaplan-Meier and Cox proportional hazards methods were used to assess LRR, DR, and OS rates and their associations with prognostic factors. RESULTS: The median age was 50 years (range, 24-83 years). The median follow-up time and median OS time for all patients were both 33 months. The 5-year actuarial OS rates were 58.7% for the entire cohort, 69.7% for ER(+) patients, 73.5% for ER(+)HER-2(+) patients, 54.0% for HER=2(+) patients, and 42.7% for TN patients (p < .0001); 5-year LRR rates were 20.3%, 8.0%, 12.6%, 22.6%, and 38.6%, respectively, for the four subgroups (p < .0001); and 5-year DR rates were 45.5%, 28.8%, 50.1%, 52.1%, and 56.7%, respectively (p < .001). OS and LRR rates were worse for TN patients than for any other subgroup (p < .0001-.03). CONCLUSIONS: TN disease is associated with worse OS, DR, and LRR outcomes in IBC patients, indicating the need for developing new locoregional and systemic treatment strategies for patients with this aggressive subtype.
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Authors | Jing Li, Ana M Gonzalez-Angulo, Pamela K Allen, Tse K Yu, Wendy A Woodward, Naoto T Ueno, Anthony Lucci, Savitri Krishnamurthy, Yun Gong, Melissa L Bondy, Wei Yang, Jie S Willey, Massimo Cristofanilli, Vicente Valero, Thomas A Buchholz |
Journal | The oncologist
(Oncologist)
Vol. 16
Issue 12
Pg. 1675-83
( 2011)
ISSN: 1549-490X [Electronic] England |
PMID | 22147002
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Receptors, Estrogen
- Receptors, Progesterone
- ErbB Receptors
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Topics |
- Adult
- Aged
- Aged, 80 and over
- ErbB Receptors
(genetics)
- Female
- Humans
- Immunohistochemistry
- In Situ Hybridization, Fluorescence
- Inflammatory Breast Neoplasms
(chemistry, diagnosis, genetics, mortality)
- Middle Aged
- Neoplasm Metastasis
- Neoplasm Recurrence, Local
(chemistry)
- Prognosis
- Receptors, Estrogen
(analysis)
- Receptors, Progesterone
(analysis)
- Retrospective Studies
- Survival Rate
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