Abstract | BACKGROUND: DESIGN AND METHODS: RESULTS: In this study of 41 patients who had at least one thrombotic event, we confirmed a very high incidence of recurrence despite anticoagulation. Nine patients with thrombosis were regarded as eligible for administration of intravenous tissue plasminogen activator, which was effective in reversing thrombi in all of 15 occasions in which it was given. Serious hemorrhagic complications developed in three cases. At last follow-up visit, of the nine patients treated, three had died, and six were in very good to excellent condition in terms of clinical outcome and radiological findings. The only patient in whom thrombolysis may have contributed to a fatal outcome also had complications of " heparin induced thrombocytopenia with thrombosis", which we diagnosed in three additional patients. In our review of the literature, nine out of 15 patients treated with thrombolysis have had a good outcome. CONCLUSIONS:
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Authors | David J Araten, Rosario Notaro, Howard T Thaler, Nancy Kernan, Farid Boulad, Hugo Castro-Malaspina, Trudy Small, Andromachi Scaradavou, Heather Magnan, Susan Prockop, Sara Chaffee, Jason Gonsky, Raymond Thertulien, Roberto Tarquini, Lucio Luzzatto |
Journal | Haematologica
(Haematologica)
Vol. 97
Issue 3
Pg. 344-52
(Mar 2012)
ISSN: 1592-8721 [Electronic] Italy |
PMID | 22133780
(Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review)
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Chemical References |
- Anticoagulants
- Fibrinolytic Agents
- Tissue Plasminogen Activator
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Topics |
- Adolescent
- Adult
- Aged
- Anticoagulants
(therapeutic use)
- Fatal Outcome
- Female
- Fibrinolytic Agents
(administration & dosage, therapeutic use)
- Hemoglobinuria, Paroxysmal
(complications, diagnosis, drug therapy)
- Humans
- Male
- Middle Aged
- Pregnancy
- Recurrence
- Risk Factors
- Thrombolytic Therapy
- Tissue Plasminogen Activator
(administration & dosage, therapeutic use)
- Treatment Outcome
- Venous Thrombosis
(diagnosis, drug therapy, etiology)
- Young Adult
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