Abstract |
Neohesperidin dihydrochalcone was administered to groups of 20 male and 20 female Wistar rats at dietary levels of 0, 0.2, 1.0 and 5.0% for 91 days. No treatment-related ophthalmoscopical, haematological or histopathological effects were observed. In the high-dose group, a marked caecal enlargement occurred in both sexes, accompanied by soft stools in the early stages of the study, somewhat lower plasma urea concentrations and increased plasma alkaline phosphatase activity and a decreased urinary pH. This group also showed slight growth depression accompanied by transient reduction in food intake; in males the body weights remained relatively low throughout the experimental period. Furthermore, bilirubin level was increased in females and total protein level was decreased in males of the high-dose group. The above changes were considered adaptive responses or chance effects rather than manifestations of clear toxicity. The low-and intermediate- dose groups did not show any compound-related untoward effect. It was concluded that the intermediate dose, providing an overall intake of about 750 mg neohesperidin dihydrochalcone per kg body weight per day, was the no-effect level.
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Authors | B A Lina, H C Dreef-van der Meulen, D C Leegwater |
Journal | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
(Food Chem Toxicol)
Vol. 28
Issue 7
Pg. 507-13
(Jul 1990)
ISSN: 0278-6915 [Print] England |
PMID | 2210523
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Proteins
- Chalcones
- Sweetening Agents
- neohesperidin dihydrochalcone
- Chalcone
- Urea
- Hesperidin
- Alkaline Phosphatase
- Bilirubin
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Topics |
- Administration, Oral
- Alkaline Phosphatase
(blood)
- Animals
- Bilirubin
(blood)
- Blood Proteins
(analysis)
- Body Weight
(drug effects)
- Cecum
(drug effects)
- Chalcone
(administration & dosage, analogs & derivatives, toxicity)
- Chalcones
- Drinking
(drug effects)
- Drug Stability
- Eating
(drug effects)
- Female
- Hesperidin
(administration & dosage, analogs & derivatives, toxicity)
- Male
- Organ Size
(drug effects)
- Random Allocation
- Rats
- Rats, Inbred Strains
- Sweetening Agents
(administration & dosage, toxicity)
- Urea
(blood)
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