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Direct comparison of the traditional and reverse syphilis screening algorithms in a population with a low prevalence of syphilis.

Abstract
We describe the first direct comparison of the reverse and traditional syphilis screening algorithms in a population with a low prevalence of syphilis. Among 1,000 patients tested, the results for 6 patients were falsely reactive by reverse screening, compared to none by traditional testing. However, reverse screening identified 2 patients with possible latent syphilis that were not detected by rapid plasma reagin (RPR).
AuthorsMatthew J Binnicker, Deborah J Jespersen, Leonard O Rollins
JournalJournal of clinical microbiology (J Clin Microbiol) Vol. 50 Issue 1 Pg. 148-50 (Jan 2012) ISSN: 1098-660X [Electronic] United States
PMID22090407 (Publication Type: Comparative Study, Evaluation Study, Journal Article)
Topics
  • Algorithms
  • Clinical Laboratory Techniques (methods)
  • Diagnostic Errors
  • Humans
  • Mass Screening (methods)
  • Prevalence
  • Sensitivity and Specificity
  • Syphilis (diagnosis)

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