Latent Syphilis

02/15/2011 - "Late cutaneous syphilis has become a rarity as a result of the effective treatment of early and latent syphilis with antibiotics. "
03/01/1997 - "Late cutaneous syphilis has become a rarity as a result of effective treatment of early and latent syphilis with antibiotics. "
04/08/1978 - "In latent syphilis and in late and congenital cases, as well as in instances of other treponemal infections, serological evidence of disease needs to be considered along with each patient's medical, social and sexual history, when and why they may have been given antibiotic treatment, and the results of radiological studies and cerebrospinal fluid examination. "
03/19/1996 - "Our study emphasizes the importance of antibiotic therapy for presumptive neurosyphilis in HIV-infected patients with latent syphilis and CSF abnormalities but nonreactive CSF-VDRL tests, even if they are neurologically asymptomatic or present with complaints inconclusive of neurosyphilis."
03/01/2019 - "Antibiotic treatment is not required for latent infections, except for latent syphilis and latent tuberculosis infections to prevent, after the primary infection, progression to the secondary or tertiary stage of the disease."

07/05/1947 - "Effect of penicillin on serology of late and latent syphilis; a study of 120 cases followed for six months or more."
01/01/2022 - "Despite treatment with penicillin, latent syphilis at ANC enrollment was associated with a more than 5-fold increased risk of LBW. "
01/01/2021 - "Latent syphilis notification of pregnant women and treatment with penicillin at the dosage of 7,200,000 IU increased. "
02/01/2020 - "We report a rare case of RPGN secondary to latent syphilis, which resolved with penicillin treatment in the absence of immunosuppressive therapy. "
02/01/2015 - "The serofast was positively associated with older age(P trend=0.001), female(summary risk ratio[sRR]=1.50, 95%CI:1.34-;1.68), latent syphilis(sRRlatent vs primary=3.17, 95%CI: 2.66-;3.77; sRRlatent vs secondary=2.00, 95%CI: 1.48-;2.69) as well as non-penicillin treatment(sRR =2.99, 95%CI:2.45-;3.67), but negatively associated with higher baseline titers(sRR>1:32 vs ≤1:32=0.63, 95%CI: 0.54-;0.75). "

07/01/2008 - "The aim of the study was to determine the characteristics of primary and late latent syphilis cases that were non-reactive on initial screening by rapid plasma reagin (RPR) but reactive by treponemal tests. "
12/09/2020 - "We are conducting a randomized, multisite, open-label, non-comparative clinical trial in Los Angeles and Oakland, CA. Eligible participants are ≥ 18 years old, with primary, secondary, or early latent syphilis (rapid plasma reagin [RPR] titer ≥ 1:8). "
01/01/2013 - "We aimed at determining the characteristics of patients with primary and late latent syphilis who were non-reactive on initial screening by rapid plasma reagin (RPR) but reactive by treponemal tests. "
01/01/2013 - "Characteristics of patients with primary and late latent syphilis patients who were initially non-reactive to the rapid plasma reagin test."
01/01/2012 - "However, reverse screening identified 2 patients with possible latent syphilis that were not detected by rapid plasma reagin (RPR)."

01/01/1981 - "Eighteen patients with latent syphilis were treated with 360 mg, 720 mg, 1080 mg or 1440 mg intramuscular procaine penicillin daily for 14 days. "
11/01/1992 - "Studies comparing ceftriaxone with 10 to 14 doses of procaine penicillin are needed to determine the most cost-effective treatment for asymptomatic neurosyphilis or presumed latent syphilis in this group of patients."
05/01/1956 - "Penicillin in late latent syphilis; results of therapy with procaine penicillin in aluminum monostearate."

03/01/1993 - "These data suggest that elicitation of a history of cocaine use from urban hospital emergency department patients may be helpful in identifying patients with latent syphilis. "
03/01/1993 - "The goal of this study was to estimate the prevalence of newly diagnosed latent syphilis, as well as previously treated syphilis, in emergency department patients giving a history of cocaine use. "
08/01/2021 - "The patient is a 64-year-old African American male with HIV, treated latent syphilis, chronic kidney disease stage 3a, and cocaine use disorder who presented with shortness of breath, bilateral lower extremities swelling, and fatigue with normal vitals and a physical exam remarkable for bibasilar inspiratory crackles with peripheral edema. "

11/01/1992 - "Although ceftriaxone achieves high serum and CSF levels, 10 to 14 days of treatment with this drug were associated with a 23% failure rate in HIV-infected patients who had latent syphilis or asymptomatic neurosyphilis. "
11/01/1992 - "To evaluate the effect of ceftriaxone in treating latent syphilis or asymptomatic neurosyphilis in patients infected with the human immunodeficiency virus (HIV). "
11/01/1992 - "Response of latent syphilis or neurosyphilis to ceftriaxone therapy in persons infected with human immunodeficiency virus."
11/01/1992 - "Thirteen patients received benzathine penicillin for presumed latent syphilis; results were similar to those observed after ceftriaxone therapy, with 8 (62%) responders, 1 (8%) serofast, 2 (15%) relapses, and 2 (15%) failures. "
11/01/1992 - "Studies comparing ceftriaxone with 10 to 14 doses of procaine penicillin are needed to determine the most cost-effective treatment for asymptomatic neurosyphilis or presumed latent syphilis in this group of patients."

01/01/2019 - "In microarray assay diagnostically high level of IgM in patients with primary, secondary and early latent and late latent syphilis decreased dramatically to zero after the successful therapy. "
01/01/2018 - "A negative TP-IgM test was found in approximately 20% and 40% of individuals with primary and early latent syphilis, respectively. "
08/01/2016 - "Clinical examination indicated he had a history of latent syphilis with negative nontreponemal and specific antitreponemal IgM tests. "
11/01/2010 - "The overall sensitivity of the IgM-PoCT was 82% and varied with clinical stage, being highest in secondary (10/10 EIA positives) but lower in primary (2/4 EIA positives) and early latent syphilis (2/3 EIA positives). "
09/01/2008 - "In 72 cases of early latent syphilis, the Murex EIA screening test was positive in 68 (94%) patients, the Mercia IgM EIA in 50 (69%) cases, the VDRL in 61 (85%) cases and the TPPA in 68 (94%) cases. "

11/01/1993 - "Asymptomatic neurosyphilis after doxycycline therapy for early latent syphilis."
01/01/2019 - "We found no statistically significant differences in serological response to treatment with doxycycline or benzathine penicillin among HIV-infected patients with early, late latent or latent syphilis of unknown duration. "
01/01/2019 - "Fifty patients treated with doxycycline from September 2014 to December 2016 were compared with 115 patients treated with benzathine penicillin for early, late latent or latent syphilis of unknown duration. "
01/01/2019 - "Although doxycycline is widely used as an alternative to benzathine penicillin for the treatment of early and late latent syphilis, data on serological response following treatment with doxycycline among HIV-infected patients are limited. "
12/15/2015 - "Doxycycline to treat early and late latent syphilis is an acceptable alternate option if penicillin cannot be used. "

03/01/2021 - "ROC analysis indicated that miR-223-3p was powerful in discriminating between controls and patients with early, primary, secondary, and latent syphilis, as well as serological cure; the miR-195-5p/miR-223-3p panel showed an improved capacity to differentiate between syphilis patients, primary, or serofast-stage syphilis and controls, while the three miRNAs combined showed an improved capacity to differentiate latent syphilis or serological cure from controls. "

12/01/2007 - "In this study, polymerase chain reaction (PCR) techniques were used to detect Treponema pallidum DNA in samples from patients with latent syphilis. "
05/01/2016 - "Molecular Subtyping and Surveillance of Resistance Genes In Treponema pallidum DNA From Patients With Secondary and Latent Syphilis in Hunan, China."
12/01/2007 - "pallidum DNA in latent syphilis."
12/01/2007 - "Detection of Treponema pallidum sp pallidum DNA in latent syphilis."
01/01/2007 - "Detection of treponema pallidum DNA in the serum of an adequately treated patient with latent syphilis."

01/01/2020 - "We aimed to investigate the CXCL13 concentration of the serum and cerebral spinal fluid (CSF) in human immunodeficiency virus (HIV)-negative latent syphilis patients with treatment failure and explore the change in CXCL13 after treatment. "
01/01/2016 - "Persistent non-treponemal titres after treatment are common among patients with latent syphilis. "
12/01/2011 - "We compared factors associated with serological response after treatment of early (ie, primary, secondary, or early latent) syphilis. "
06/01/1984 - "Twenty-six patients with secondary or early latent syphilis were examined by auditory brainstem response (ABR) audiometry and by pure tone audiometry before and after treatment. "
02/01/1983 - "The natural killer cell activity was studied in 25 patients with primary, secondary, or latent syphilis before and after treatment. "

01/01/2022 - "Investigating latent syphilis in HIV treatment-experienced Ethiopians and response to therapy."
11/12/2014 - "Less evidence is available regarding therapy for late and late latent syphilis. "
01/01/2006 - "Diagnostic criteria of EGS are the following: serologically confirmed manifest or latent syphilis, poor effect of standard antiulcer treatment, rapid elimination of the disease symptoms in antisyphilis therapy and positive changes in pathological alterations in gastric mucosa."
01/01/1989 - "Seven patients with latent syphilis are described, in whom the routine serologic tests (RST) were negative during the first examination and over the course of therapy, and the specific tests (T. "
04/01/1979 - "[Overall therapy of latent syphilis]."

02/01/1997 - "In the multivariate analysis, the significant factors for CS were lack of prenatal care and late latent syphilis. "
11/27/2019 - "Women in concordant couples were more likely to have higher parity, more children, late antenatal care and syphilis screening, a lower proportion of latent syphilis, and elevated serologic titers than women in discordant couples (P < 0.01 for all). "
08/01/2006 - "Delayed or absent prenatal care and misinterpretation of syphilis serology (or laboratory failures) in the presence of latent syphilis are mostly responsible for the inadequate management of syphilis during pregnancy and thus the occurrence of CS."

01/01/2013 - "Late latent syphilis in two hemodialysis units."
04/01/2014 - "After the completion of an oral desensitization protocol, the standard three-dose regimen of intramuscular penicillin G for late latent syphilis was safely administered to a hemodialysis patient without dosage adjustment or repeated desensitization."

05/01/1989 - "[Results of the treatment of neurosyphilis and seroresistant latent syphilis by intravenous administration of potassium salt of penicillin G]."