Transgenic rice accumulating modified cedar pollen allergen Cry j 2 derivatives.

Abstract

In order to create a safe tolerogenic antigen with reduced IgE reactivity, we developed transgenic rice that accumulates in the seed endosperm a sufficient amount of Cry j 2, the cedar pollen allergen, in a restructured form of tail-to-head, providing a feasible mucosal allergy vaccine against cedar pollinosis.

• Authors: Kazuya Suzuki, Lijun Yang, Fumio Takaiwa
• Journal: Journal of bioscience and bioengineering (J Biosci Bioeng) Vol. 113 Issue 2 Pg. 249-51 (Feb 2012) ISSN: 1347-4421 [Electronic] Japan
• PMID: 22055918 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Chemical References

• Allergens
• Antigens, Plant
• Cry j II protein, Cryptomeria japonica
• Plant Proteins
• Immunoglobulin E

Topics

• Allergens (biosynthesis, genetics, immunology)
• Antigens, Plant (biosynthesis, genetics, immunology)
• Cryptomeria (immunology)
• Immunoglobulin E (immunology)
• Oryza (genetics, metabolism)
• Plant Proteins (biosynthesis, genetics, immunology)
• Plants, Genetically Modified (metabolism)
• Pollen (immunology)
• Seeds (metabolism)