Survival impact of adjuvant paclitaxel and carboplatin for early-stage ovarian clear-cell carcinoma with complete surgical staging.

Abstract

OBJECTIVES:

The aim of this study was to estimate the survival impact of adjuvant paclitaxel and carboplatin (TC) compared to cisplatin (CDDP)-based chemotherapies for early-stage ovarian clear-cell carcinoma (CCC).

METHODS:

Clinicopathologic information on 99 stage I-II CCC patients was obtained between 1987 and 2005. All patients underwent complete surgical staging including systemic lymphadenectomy, followed by TC or various CDDP-based regimens. In the present study, only CCC patients with no residual tumor were enrolled.

RESULTS:

The median age was 53 years and ranged from 30 to 69 years. Fifty-three (53.5%) patients received TC and 46 (46.5%) patients underwent various CDDP-based chemotherapies after initial surgery. Five-year progression-free survival (PFS) rates of TC and various CDDP groups were 66.5 and 75.8%, respectively (n.s., p = 0.933). In addition, 5-year overall survival (OS) rates of TC and various CDDP groups were 82.4 and 82.3%, respectively (n.s., p = 0.583). In multivariate analyses of OS and PFS, the regimen of chemotherapywas not a significant prognostic factor (OS, p = 0.502; PFS, p = 0.977.

CONCLUSIONS:

In our current examination of the long-term survival of early-stage CCC patients, we did not identify a superiority of TC over various CDDP-based regimens as frontline adjuvant chemotherapy.

• Authors: Hiroaki Kajiyama, Kiyosumi Shibata, Shiro Suzuki, Kazuhiko Ino, Michiyasu Kawai, Tetsuro Nagasaka, Akihiro Nawa, Fumitaka Kikkawa
• Journal: Gynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 72 Issue 4 Pg. 252-6 ( 2011) ISSN: 1423-002X [Electronic] Switzerland
• PMID: 22041903 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 S. Karger AG, Basel.

Chemical References

• Carboplatin
• Paclitaxel
• Cisplatin

Topics

• Adenocarcinoma, Clear Cell (drug therapy, mortality, surgery)
• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
• Carboplatin (administration & dosage)
• Chemotherapy, Adjuvant
• Cisplatin (administration & dosage)
• Female
• Follow-Up Studies
• Humans
• Middle Aged
• Neoplasm Staging
• Ovarian Neoplasms (drug therapy, mortality, surgery)
• Paclitaxel (administration & dosage)
• Prognosis
• Retrospective Studies
• Survival Rate