Liver-intestine cadherin in intraepithelial neoplasia of intrahepatic cholangiocarcinoma.

Abstract

BACKGROUND/AIMS:

Liver-intestine cadherin (LI-cadherin) is a member of the cadherin superfamily and aberrant expression of LI-cadherin is associated with intestinal metaplasia. The aim of this study was to identify factors associated with LI-cadherin expression in biliary intraepithelial lesions of intrahepatic cholangiocarcinoma (ICC).

METHODOLOGY:

We evaluated the immunoreactivity of LI-cadherin, MUC2, CDX2, MUC5AC and HGM, according to the grade of biliary intraepithelial lesion in 16 resected specimens of ICC without hepatolithiasis.

RESULTS:

A total of 168 biliary intraepithelial lesions were classified into four grades: reactive change (42 lesions), biliary intraepithelial neoplasia (BilIN)-1 (10 lesions), BilIN-2 (40 lesions) and BilIN-3 (76 lesions). Biliary intraepithelial lesions were classified into three mucin phenotypes: null (46 lesions), gastric (97 lesions) and gastrointestinal phenotype (25 lesions). LI-cadherin expression was found in 45 (27%) of 168 biliary intraepithelial lesions. BilIN-2/3 (p<0.001), gastrointestinal phenotype (p=0.006) and CDX2 expression (p=0.002) were significantly associated with LI-cadherin expression. Logistic regression analysis revealed that BilIN-2/3 (p=0.002) was the only independently significant factor associated with LI-cadherin expression.

CONCLUSIONS:

The grade of BilIN independently correlates with LI-cadherin expression in biliary intraepithelial lesions of ICC without hepatolithiasis, whereas the mucin phenotype or CDX2 expression does not.

• Authors: Makoto Inoue, Yoichi Ajioka, Toshifumi Wakai, Masaaki Takamura, Pavel Korita, Yoshio Shirai, Katsuyoshi Hatakeyama
• Journal: Hepato-gastroenterology (Hepatogastroenterology) 2011 Nov-Dec Vol. 58 Issue 112 Pg. 2045-51 ISSN: 0172-6390 [Print] Greece
• PMID: 22024075 (Publication Type: Journal Article)

Chemical References

• CDH17 protein, human
• CDX2 Transcription Factor
• CDX2 protein, human
• Cadherins
• Homeodomain Proteins
• MUC2 protein, human
• Mucin-2

Topics

• Adult
• Aged
• Bile Duct Neoplasms (pathology)
• Bile Ducts, Intrahepatic
• CDX2 Transcription Factor
• Cadherins (analysis, physiology)
• Cholangiocarcinoma (classification, pathology)
• Female
• Homeodomain Proteins (analysis)
• Humans
• Liver Neoplasms (classification, pathology)
• Logistic Models
• Male
• Middle Aged
• Mucin-2 (analysis)