Abstract | BACKGROUND: METHODS: Urine was collected from 56 untreated volunteers and 143 patients with CRC before adjuvant treatment. Ura and UH(2) were analyzed using a column-switching high-performance liquid chromatography method that incorporates reversed-phase and cation-exchange columns. Ura, UH(2), and UH(2)/Ura levels were related to toxicity. RESULTS: Ura and UH(2) in patients were not different from controls. UH(2) was significantly higher in women compared with men. The UH(2)/Ura ratio, however, did not differ according to sex. Low UH(2) and UH(2)/Ura levels were associated with diarrhea in men. Women experiencing thrombocytopenia had significantly higher Ura compared with women with no thrombocytopenia. The UH(2)/Ura ratio correlated negatively with total toxicity score in men (r = -0.39, P = .020). CONCLUSION: Pretherapeutic Ura and UH(2) levels per se may be related to risk of side effects during adjuvant 5-FU-based treatment, whereas the UH(2)/Ura ratio may not always reveal such a risk. Sex is a strong risk factor for toxicity, showing the importance of evaluating male and female patients separately.
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Authors | Yvonne Wettergren, Göran Carlsson, Elisabeth Odin, Bengt Gustavsson |
Journal | Cancer
(Cancer)
Vol. 118
Issue 11
Pg. 2935-43
(Jun 01 2012)
ISSN: 1097-0142 [Electronic] United States |
PMID | 22020693
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 American Cancer Society. |
Chemical References |
- Organoplatinum Compounds
- dihydrouracil
- Oxaliplatin
- Uracil
- Fluorouracil
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Chemotherapy, Adjuvant
- Colorectal Neoplasms
(complications, drug therapy, metabolism)
- Diarrhea
(urine)
- Dihydropyrimidine Dehydrogenase Deficiency
(complications)
- Female
- Fluorouracil
(adverse effects)
- Humans
- Male
- Middle Aged
- Organoplatinum Compounds
(administration & dosage)
- Oxaliplatin
- Sex Characteristics
- Thrombocytopenia
(urine)
- Uracil
(analogs & derivatives, urine)
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