Abstract |
We evaluated the efficacy and safety of an oral rehydration solution containing glycyl-glycine, glycine, and maltodextrin (GGG- ORS), in comparison to the glucose based ORS (standard ORS). The osmolality of the GGG- ORS (305 mOsm/l) and standard ORS (311 mOsm/l) was similar. Ninety-two children presenting with acute gastroenteritis and moderate dehydration, aged 3 months to 3 years, were randomly assigned to receive standard ORS or GGG- ORS. All the patients were successfully rehydrated orally. The two groups were comparable for baseline characteristics including the microbial etiology. Rotavirus (49%, 36%), ETEC (11%, 18%) or a combination of rotavirus and ETEC (15%, 9%) were the main stool pathogens isolated. There was no significant difference in the mean stool output or duration of diarrhoea between the two groups. Patients in the GGG- ORS group had higher urine output (p less than 0.01) and weight gain (p less than 0.05) in the initial 6 hours when feeding was withheld, but no such differences were observed beyond this period. Hypernatremia did not develop in any patient during the study. We conclude that glycine and glycyl-glycine supplemented oral rehydration solution does not have any therapeutic advantage in the treatment of acute gastroenteritis with moderate dehydration caused predominantly by rotavirus.
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Authors | M K Bhan, S Sazawal, S Bhatnagar, N Bhandari, D K Guha, S K Aggarwal |
Journal | Acta paediatrica Scandinavica
(Acta Paediatr Scand)
Vol. 79
Issue 5
Pg. 518-26
(May 1990)
ISSN: 0001-656X [Print] Sweden |
PMID | 2201165
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Polysaccharides
- Rehydration Solutions
- maltodextrin
- Glycine
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Topics |
- Acute Disease
- Child, Preschool
- Dehydration
(etiology, therapy)
- Double-Blind Method
- Fluid Therapy
(methods)
- Gastroenteritis
(complications, therapy)
- Glycine
(administration & dosage)
- Humans
- Infant
- Male
- Polysaccharides
(administration & dosage)
- Randomized Controlled Trials as Topic
- Rehydration Solutions
(therapeutic use)
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