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Kaempferol regulates OPN-CD44 pathway to inhibit the atherogenesis of apolipoprotein E deficient mice.

Abstract
Recent studies show that osteopontin (OPN) and its receptor cluster of differentiation 44 (CD44) are two pro-inflammatory cytokines contributing to the development of atherosclerosis. The objective of this study was to explore the inhibitory effect of kaempferol, a naturally occurring flavonoid compound, on atherogenesis and the mechanisms involved. The experiments were performed in aorta and plasma from C57BL/6J control and apolipoprotein E-deficient (ApoE(-/-)) mice treated or not with kaempferol (50 or 100mg/kg, intragastrically) for 4 weeks. Kaempferol treatment decreased atherosclerotic lesion area, improved endothelium-dependent vasorelaxation, and increased the maximal relaxation value concomitantly with decrease in the half-maximum effective concentration, plasma OPN level, aortic OPN expression, and aortic CD44 expression in ApoE(-/-) mice. In addition, treatment with kaempferol also significantly decreased reactive oxygen species production in mice aorta. The present results suggest that kaempferol regulates OPN-CD44 pathway to inhibit the atherogenesis of ApoE(-/-) mice.
AuthorsHong-Bo Xiao, Xiang-Yang Lu, Zhi-Liang Sun, Heng-Bo Zhang
JournalToxicology and applied pharmacology (Toxicol Appl Pharmacol) Vol. 257 Issue 3 Pg. 405-11 (Dec 15 2011) ISSN: 1096-0333 [Electronic] United States
PMID22005275 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Elsevier Inc. All rights reserved.
Chemical References
  • Apolipoproteins E
  • Hyaluronan Receptors
  • Kaempferols
  • Reactive Oxygen Species
  • Osteopontin
  • kaempferol
Topics
  • Animals
  • Aorta (drug effects, metabolism)
  • Apolipoproteins E (genetics)
  • Atherosclerosis (drug therapy, pathology)
  • Dose-Response Relationship, Drug
  • Endothelium, Vascular (drug effects, pathology)
  • Gene Expression Regulation (drug effects)
  • Hyaluronan Receptors (drug effects, metabolism)
  • Kaempferols (administration & dosage, pharmacology)
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Osteopontin (blood, drug effects, metabolism)
  • Reactive Oxygen Species (metabolism)
  • Vasodilation (drug effects)

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