Abstract |
Atrial fibrillation (AF) is recognised as the most common sustained cardiac arrhythmia in clinical practice. Ongoing drug development is aiming at obtaining atrial specific effects in order to prevent pro-arrhythmic, devastating ventricular effects. In principle, this is possible due to a different ion channel composition in the atria and ventricles. The present text will review the aetiology of arrhythmias with focus on AF and include a description of cardiac ion channels. Channels that constitute potentially atria-selective targets will be described in details. Specific focus is addressed to the recent discovery that Ca(2+)-activated small conductance K(+) channels (SK channels) are important for the repolarisation of atrial action potentials. Finally, an overview of current pharmacological treatment of AF is included.
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Authors | Morten Grunnet, Bo Hjorth Bentzen, Ulrik Svane Sørensen, Jonas Goldin Diness |
Journal | Reviews of physiology, biochemistry and pharmacology
(Rev Physiol Biochem Pharmacol)
Vol. 162
Pg. 1-58
( 2012)
ISSN: 0303-4240 [Print] Germany |
PMID | 21987061
(Publication Type: Journal Article, Review)
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Chemical References |
- Anti-Arrhythmia Agents
- Calcium Channel Blockers
- Ion Channels
- Ions
- Potassium Channel Blockers
- Potassium Channels
- Calcium
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Topics |
- Action Potentials
- Animals
- Anti-Arrhythmia Agents
(pharmacology)
- Arrhythmias, Cardiac
(drug therapy, physiopathology)
- Atrial Fibrillation
(drug therapy, physiopathology, prevention & control)
- Calcium
(metabolism)
- Calcium Channel Blockers
(pharmacology)
- Electrophysiology
- Heart
(physiology)
- Humans
- Ion Channels
(metabolism)
- Ions
- Models, Biological
- Potassium Channel Blockers
(pharmacology)
- Potassium Channels
(metabolism)
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