Protective effect of vanillin against carbon tetrachloride (CCl₄)-induced oxidative brain injury in rats.

Abstract

This study investigated the protective effects of vanillin against acute brain damage induced by carbon tetrachloride (CCl₄) in rats. The study was performed on 32 male rats divided into four groups: a control group, vanillin group ([Va] 150 mg/kg/day, intraperitoneally [i.p.]) and CCl₄ toxication groups received a single injection of CCl₄ (1 ml/kg, i.p.; CCl₄ and Va + CCl₄ groups). The degree of protection in brain tissue was evaluated by the levels of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase, glutathione transferase, glutathione peroxidase and nitric oxide (NO). Vanillin showed a significant brain-protective effect by decreasing the level of lipid peroxidation and NO₂ and elevated the activities of antioxidative enzymes and level of GSH. Consequently vanillin blocked oxidative brain damage induced by CCl₄ in rats.

• Authors: Mohamed Makni, Yassine Chtourou, Mohamed Barkallah, Hamadi Fetoui
• Journal: Toxicology and industrial health (Toxicol Ind Health) Vol. 28 Issue 7 Pg. 655-62 (Aug 2012) ISSN: 1477-0393 [Electronic] England
• PMID: 21986887 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Benzaldehydes
• Nitric Oxide
• Malondialdehyde
• vanillin
• Carbon Tetrachloride
• Oxidoreductases
• Glutathione Transferase
• Acetylcholinesterase

Topics

• Acetylcholinesterase (metabolism)
• Analysis of Variance
• Animals
• Antioxidants (pharmacology)
• Benzaldehydes (pharmacology)
• Brain Chemistry (drug effects)
• Brain Injuries (chemically induced, metabolism, prevention & control)
• Carbon Tetrachloride (toxicity)
• Glutathione Transferase (metabolism)
• Male
• Malondialdehyde (analysis)
• Nitric Oxide (analysis)
• Oxidative Stress (drug effects)
• Oxidoreductases (metabolism)
• Rats
• Rats, Wistar