Relationship between circulating cytokine levels and physical or psychological functioning in patients with advanced cancer.

Abstract

OBJECTIVE:

To investigate the relation between functional impairments of cancer patients and circulating cytokines using a multiplex technique.

DESIGN AND METHODS:

50 patients with cancer were assessed using the quality of life (QOL) questionnaire. 27 plasma cytokine levels were determined by using the Bio-Plex array system. The relation to QOL scores was assessed using Chi-square test for categorical variables and univariate linear regression analysis for cytokine levels.

RESULTS:

Multivariate analysis showed that interleukin-6 (IL-6) level is a significant independent determinant of physical (β=-0.238, P=0.0126) and cognitive functioning (β=-0.462, P=0.0006) and that vascular endothelial growth factor (VEGF) level is a significant independent determinant of emotional functioning (β=-0.414, P=0.039).

CONCLUSION:

This study, in which 27 cytokines are simultaneously tested with cutting edge technology, demonstrates that plasma IL-6 and VEGF are significant independent determinants of functional impairments in patients with cancer.

• Authors: Takeshi Ishikawa, Satoshi Kokura, Naoyuki Sakamoto, Manabu Okajima, Tatsuzo Matsuyama, Hiromi Sakai, Yoko Okumura, Satoko Adachi, Naohisa Yoshida, Kazuhiko Uchiyama, Osamu Handa, Tomohisa Takagi, Hideyuki Konishi, Naoki Wakabayashi, Nobuaki Yagi, Takashi Ando, Kazuko Uno, Yuji Naito, Toshikazu Yoshikawa
• Journal: Clinical biochemistry (Clin Biochem) Vol. 45 Issue 3 Pg. 207-11 (Feb 2012) ISSN: 1873-2933 [Electronic] United States
• PMID: 21963382 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier B.V. All rights reserved.

Chemical References

• Cytokines

Topics

• Adult
• Aged
• Aged, 80 and over
• Cognition
• Cytokines (blood)
• Female
• Humans
• Male
• Middle Aged
• Neoplasm Staging
• Neoplasms (blood, pathology, physiopathology, psychology)
• Regression Analysis
• Young Adult