Abstract |
Abana is a herbomineral medicinal preparation with a property of down-regulation of beta-adrenergic receptors. A double-blind, parallel group study was conducted in 43 Indian men and women suffering from hypertension to evaluate the antihypertensive effect of Abana and compare it with that of methyldopa (M- DOPA). Twenty-one patients received 800 mg tds of Abana and 22 patients received 250 mg tds of M- DOPA for 4 weeks. Blood pressure and pulse rate were recorded at weekly intervals. Relevant clinical and biochemical investigations were carried out before and after treatment. In patients treated with Abana, there was a significant fall both in systolic B.P. (from 167 +/- 3.73 to 145 +/- 6.11 mmHg) and in diastolic B.P. (from 110 +/- 1.86 to 91 +/- 3.04 mmHg) at the end of 4 weeks. Similarly in patients treated with M- DOPA, systolic blood pressure was significantly reduced from 165 +/- 4.92 to 146 +/- 4.9 mmHg and diastolic blood pressure was reduced from 106 +/- 2.74 to 96 +/- 2.67 mmHg after 4 weeks. The onset of antihypertensive effect was earlier and there was a higher percentage of responders (80%) in the Abana-treated group. None of the patients had clinically or biochemically significant side-effects. The results of this study suggest that therapy with Abana proved highly effective in hypertensive patients.
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Authors | V N Dadkar, R R Tahiliani, V S Jaguste, V B Damle, H L Dhar |
Journal | Japanese heart journal
(Jpn Heart J)
Vol. 31
Issue 2
Pg. 193-9
(Mar 1990)
ISSN: 0021-4868 [Print] Japan |
PMID | 2192099
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Minerals
- Plant Extracts
- abana
- Methyldopa
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Topics |
- Adult
- Aged
- Blood Pressure
(drug effects)
- Double-Blind Method
- Female
- Humans
- Hypertension
(drug therapy, metabolism, physiopathology)
- Male
- Methyldopa
(adverse effects, therapeutic use)
- Middle Aged
- Minerals
(adverse effects, therapeutic use)
- Plant Extracts
(adverse effects, therapeutic use)
- Randomized Controlled Trials as Topic
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