Coprismycins A and B, neuroprotective phenylpyridines from the dung beetle-associated bacterium, Streptomyces sp.

Abstract

Two new phenylpyridines, named coprismycins A and B (1 and 2), and previously reported dipyridines (3-6) were isolated from a culture of Streptomyces sp. associated with the dung beetle, Copris tripartitus. The structures of the coprismycins (1 and 2) were elucidated by the analysis of 1D and 2D NMR spectra and mass, UV, and IR spectra. Coprismycins A-B (1 and 2) and dipyridines (5 and 6) displayed comparable neuroprotective effects against MPP(+) (1-methyl-4-phenylpyrimidium)-induced neurotoxicity in neuroblastoma SH-SY5Y cells.

• Authors: Seong-Hwan Kim, Hyeonseok Ko, Hea-Son Bang, Seon-Hui Park, Dong-Gyu Kim, Hak Cheol Kwon, Sun Yeou Kim, Jongheon Shin, Dong-Chan Oh
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 21 Issue 19 Pg. 5715-8 (Oct 01 2011) ISSN: 1464-3405 [Electronic] England
• PMID: 21873059 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ltd. All rights reserved.

Chemical References

• Neuroprotective Agents
• Oximes
• Pyridines
• coprismycin A
• 1-Methyl-4-phenylpyridinium
• Dopamine

Topics

• 1-Methyl-4-phenylpyridinium (toxicity)
• Animals
• Cell Line, Tumor
• Cell Survival
• Coleoptera (microbiology)
• Dopamine (metabolism)
• Drug Discovery
• Molecular Structure
• Neuroblastoma
• Neuroprotective Agents (chemistry, isolation & purification, pharmacology, toxicity)
• Neurotoxicity Syndromes (drug therapy, prevention & control)
• Oximes (chemistry, isolation & purification, pharmacology, toxicity)
• Parkinsonian Disorders (drug therapy, prevention & control)
• Pyridines (chemistry, isolation & purification, pharmacology, toxicity)
• Streptomyces (chemistry)