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A novel preparation method for camptothecin (CPT) loaded folic acid conjugated dextran tumor-targeted nanoparticles.

Abstract
In this study, folic-dextran-camptothecin (Fa-DEX-CPT) tumor-targeted nanoparticles were produced with a supercritical antisolvent (SAS) technique by using dimethyl sulfoxide (DMSO) as a solvent and carbon dioxide as an antisolvent. A factorial design was used to reveal the effect of various process parameters on the mean particle size (MPS) and morphology of the particles formed. Under the optimum operation conditions, Fa-DEX-CPT nanoparticles with a MPS of 182.21 nm were obtained. Drug encapsulation efficiency and loading efficiency were 62.13% and 36.12%, respectively. It was found that the concentrations of the camptothecin (CPT) and dextran solution had a major influence upon morphology and shape of the final product. In addition, the samples were characterized by Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) with the purpose of developing a suitable targeted drug delivery system for cancer chemotherapy.
AuthorsYuangang Zu, Dan Wang, Xiuhua Zhao, Ru Jiang, Qi Zhang, Dongmei Zhao, Yong Li, Baishi Zu, Zhiqiang Sun
JournalInternational journal of molecular sciences (Int J Mol Sci) Vol. 12 Issue 7 Pg. 4237-49 ( 2011) ISSN: 1422-0067 [Electronic] Switzerland
PMID21845075 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Dextrans
  • Drug Carriers
  • Carbon Dioxide
  • Folic Acid
  • Camptothecin
  • Dimethyl Sulfoxide
Topics
  • Antineoplastic Agents, Phytogenic (chemistry)
  • Calorimetry, Differential Scanning
  • Camptothecin (chemistry)
  • Carbon Dioxide (chemistry)
  • Chemistry, Pharmaceutical
  • Dextrans (chemistry)
  • Dimethyl Sulfoxide (chemistry)
  • Drug Carriers (chemistry)
  • Folic Acid (chemistry)
  • Microscopy, Electron, Scanning
  • Nanoparticles (chemistry, ultrastructure)
  • Particle Size
  • Spectroscopy, Fourier Transform Infrared
  • Surface Properties
  • X-Ray Diffraction

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