Abstract |
In this study, folic- dextran- camptothecin (Fa-DEX- CPT) tumor-targeted nanoparticles were produced with a supercritical antisolvent (SAS) technique by using dimethyl sulfoxide ( DMSO) as a solvent and carbon dioxide as an antisolvent. A factorial design was used to reveal the effect of various process parameters on the mean particle size (MPS) and morphology of the particles formed. Under the optimum operation conditions, Fa-DEX- CPT nanoparticles with a MPS of 182.21 nm were obtained. Drug encapsulation efficiency and loading efficiency were 62.13% and 36.12%, respectively. It was found that the concentrations of the camptothecin ( CPT) and dextran solution had a major influence upon morphology and shape of the final product. In addition, the samples were characterized by Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) with the purpose of developing a suitable targeted drug delivery system for cancer chemotherapy.
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Authors | Yuangang Zu, Dan Wang, Xiuhua Zhao, Ru Jiang, Qi Zhang, Dongmei Zhao, Yong Li, Baishi Zu, Zhiqiang Sun |
Journal | International journal of molecular sciences
(Int J Mol Sci)
Vol. 12
Issue 7
Pg. 4237-49
( 2011)
ISSN: 1422-0067 [Electronic] Switzerland |
PMID | 21845075
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Dextrans
- Drug Carriers
- Carbon Dioxide
- Folic Acid
- Camptothecin
- Dimethyl Sulfoxide
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Topics |
- Antineoplastic Agents, Phytogenic
(chemistry)
- Calorimetry, Differential Scanning
- Camptothecin
(chemistry)
- Carbon Dioxide
(chemistry)
- Chemistry, Pharmaceutical
- Dextrans
(chemistry)
- Dimethyl Sulfoxide
(chemistry)
- Drug Carriers
(chemistry)
- Folic Acid
(chemistry)
- Microscopy, Electron, Scanning
- Nanoparticles
(chemistry, ultrastructure)
- Particle Size
- Spectroscopy, Fourier Transform Infrared
- Surface Properties
- X-Ray Diffraction
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