Performance of glycogen phosphorylase isoenzyme BB is weak in the detection of patients with non-ST-elevation acute coronary syndrome.

Abstract

OBJECTIVE:

To examine the diagnostic performance of glycogen-phosphorylase-isoenzyme-BB (GPBB) combined with cardiac troponin I (cTnI) in acute coronary syndrome (ACS).

DESIGN AND METHODS:

Sixty patients with chest pain were investigated; GPBB and cTnI were measured.

RESULTS:

ACS was confirmed in 31 patients; cTnI was >0.07 μg/L in 15 patients and GPBB was >10 μg/L in 6 patients. Areas under ROC curves were similar: 0.854 (cTnI+GPBB) vs. 0.843 (cTnI), p=0.728.

CONCLUSION:

Combination of GPBB with cTnI does not improve the detection of ACS.

• Authors: Christophe Meune, Karim Wahbi, Simon Weber, Stéphane Zuily, Luc Cynober, Camille Chenevier-Gobeaux
• Journal: Clinical biochemistry (Clin Biochem) Vol. 44 Issue 16 Pg. 1343-5 (Nov 2011) ISSN: 1873-2933 [Electronic] United States
• PMID: 21820423 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 2011">The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Troponin I
• Glycogen Phosphorylase
• glycogen phosphorylase BB, human

Topics

• Acute Coronary Syndrome (blood, diagnosis, enzymology)
• Biomarkers (blood)
• Chest Pain (blood, diagnosis)
• Female
• Glycogen Phosphorylase (blood)
• Humans
• Male
• Middle Aged
• Troponin I (blood)