Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: a test-negative case control study.

Abstract	We aimed to estimate the effectiveness of H1N1/09 containing influenza vaccines against hospitalization from influenza in Australia. We performed a test-negative case control study in patients hospitalized in 15 sentinel Australian hospitals between March and November 2010, comparing influenza vaccination (H1N1/09 monovalent or 2010 seasonal trivalent) in hospitalized patients with PCR-confirmed influenza compared to PCR-negative controls. Between March and November 2010, 1169 hospitalized patients were tested for suspected influenza, of which influenza vaccine status was ascertained in 165/238 patients with H1N1/09 influenza, 40/64 with seasonal influenza and 558/867 test negative controls; 24% of H1N1/09 cases, 43% of seasonal influenza cases and 54% of controls were vaccinated. VE against hospitalisation with H1N1/09 influenza after adjusting for age, medical comorbidities and pregnancy status was estimated at 49% (95% CI: 13%, 70%). Influenza vaccination was associated with a reduction in hospitalisation caused by H1N1/09 influenza in the 2010 southern hemisphere winter season.
Authors	Allen C Cheng, Tom Kotsimbos, Heath A Kelly, Louis B Irving, Simon D Bowler, Simon G A Brown, Mark Holmes, Christine R Jenkins, Philip Thompson, Graham Simpson, Richard Wood-Baker, Sanjaya N Senanayake, Stephen J Brady, David L Paterson, Peter A Wark, John W Upham, Tony M Korman, Dominic E Dwyer, Grant W Waterer, Paul M Kelly
Journal	Vaccine (Vaccine) Vol. 29 Issue 43 Pg. 7320-5 (Oct 06 2011) ISSN: 1873-2518 [Electronic] Netherlands
PMID	21810450 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright	Copyright © 2011 Elsevier Ltd. All rights reserved.
Chemical References	Influenza Vaccines
Topics	Adolescent Adult Aged Australia Case-Control Studies Child Female Hospitalization Humans Influenza A Virus, H1N1 Subtype (immunology) Influenza Vaccines (immunology) Influenza, Human (immunology, prevention & control) Male Middle Aged Treatment Outcome Vaccination

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