Abstract | OBJECTIVE: METHODS: RESULTS: Rats submitted to models of chemotherapy-induced and alcohol-induced neuropathy developed persistent muscle hyperalgesia, which evolved in parallel in muscle and skin. The administration of PKCε AS, which has been shown to mediate cutaneous hyperalgesia in paclitaxel and ethanol models of neuropathic pain, also inhibited muscle hyperalgesia induced by these agents. Stopping AS-ODN was associated with the reappearance of hyperalgesia at both sites. The AS-ODN to PKCε treatment was devoid of effect in both muscle and skin in the oxaliplatin neuropathy model. INTERPRETATION: Our results support the suggestion that neuropathic muscle pain may be a greater clinical problem than generally appreciated.
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Authors | Pedro Alvarez, Luiz F Ferrari, Jon D Levine |
Journal | Annals of neurology
(Ann Neurol)
Vol. 70
Issue 1
Pg. 101-9
(Jul 2011)
ISSN: 1531-8249 [Electronic] United States |
PMID | 21786301
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2011 American Neurological Association. |
Chemical References |
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Topics |
- Alcohol Drinking
(adverse effects, pathology)
- Alcoholic Neuropathy
(etiology, pathology)
- Animals
- Antineoplastic Agents
(toxicity)
- Disease Models, Animal
- Male
- Muscle, Skeletal
(drug effects, pathology)
- Pain
(chemically induced, etiology, pathology)
- Pain Measurement
(methods)
- Peripheral Nervous System Diseases
(chemically induced, pathology)
- Rats
- Rats, Sprague-Dawley
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