The recent updates of therapeutic approaches against aβ for the treatment of Alzheimer's disease.

Abstract

One of the main neuropathological lesions observed in brain autopsy of Alzheimer's disease (AD) patients is the extracellular senile plaques mainly composed of amyloid-beta (Aβ) peptide. Recently, treatment strategies have focused on modifying the formation, clearance, and accumulation of this potentially neurotoxic peptide. β- and γ-secretase are responsible for the cleavage of amyloid precursor protein (APP) and the generation of Aβ peptide. Treatments targeting these two critical secretases may therefore reduce Aβ peptide levels and positive impact on AD. Vaccination is also an advanced approach against Aβ. This review focuses on recent advances of our understanding of this key peptide, with emphasis on Aβ peptide synthesis, accumulation and neurotoxicity, and current therapies including vaccination and two critical secretase inhibitors. MicroRNAs (miRNAs) are a class of conserved endogenous small noncoding RNAs, known to regulate the expression of complementary messenger RNAs, involved in AD development. We therefore address the relationship of miRNAs in the brain and Aβ generation, as a novel therapeutic approach to the treatment of AD while also providing new insights on the etiology of this neurological disorder.

• Authors: Shucai Ling, Jing Zhou, John A Rudd, Zhiying Hu, Marong Fang
• Journal: Anatomical record (Hoboken, N.J. : 2007) (Anat Rec (Hoboken)) Vol. 294 Issue 8 Pg. 1307-18 (Aug 2011) ISSN: 1932-8494 [Electronic] United States
• PMID: 21717585 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2011 Wiley-Liss, Inc.

Chemical References

• Alzheimer Vaccines
• Amyloid beta-Peptides
• Enzyme Inhibitors
• MicroRNAs
• Amyloid Precursor Protein Secretases
• Aspartic Acid Endopeptidases
• BACE1 protein, human

Topics

• Alzheimer Disease (genetics, metabolism, therapy)
• Alzheimer Vaccines (therapeutic use)
• Amyloid Precursor Protein Secretases (antagonists & inhibitors, genetics)
• Amyloid beta-Peptides (genetics, immunology, metabolism)
• Animals
• Aspartic Acid Endopeptidases (antagonists & inhibitors, genetics)
• Brain (drug effects, metabolism)
• Enzyme Inhibitors (therapeutic use)
• Gene Expression Regulation
• Genetic Therapy
• Humans
• MicroRNAs (metabolism)