Clinical applications of NGF in ocular diseases.

Abstract

Nerve Growth Factor (NGF) and its receptors TrkA and p75 are expressed in physiological states in the anterior and posterior segments of the human eye, where they exert several tissue-specific functions. The roles played by NGF in the homeostasis of the eye and in vision are, therefore, crucial and have been widely investigated both in vitro and in vivo, with growing evidence of an NGF-pathway alteration in several ocular diseases. In this review we describe the functions of NGF in health and diseases states of the eye, and discuss the potential therapeutic effectiveness of NGF in preliminary clinical reports performed in severe ocular diseases unresponsive to any standard treatment. In fact, pharmacodynamic studies showing that NGF administered topically on the ocular surface affects not only the ocular surface but is also able to reach the retina, optic nerve and brain, recently opened new perspectives for the treatment of challenging ocular surface diseases, optic nerve diseases, and degenerative diseases of the retina currently lacking an effective therapy.

• Authors: Alessandro Lambiase, Flavio Mantelli, Marta Sacchetti, Simona Rossi, Luigi Aloe, Stefano Bonini
• Journal: Archives italiennes de biologie (Arch Ital Biol) Vol. 149 Issue 2 Pg. 283-92 (Jun 2011) ISSN: 0003-9829 [Print] Italy
• PMID: 21702001 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Nerve Growth Factor

Topics

• Administration, Ophthalmic
• Eye Diseases (classification, drug therapy)
• Humans
• Nerve Growth Factor (therapeutic use)