Effectiveness of three times daily lansoprazole/amoxicillin dual therapy for Helicobacter pylori infection in Korea.

Abstract

AIM:

We compared three times daily dual therapy with standard triple therapy for effectiveness and safety in H. pylori infection.

METHODS:

Two hundred and four H. pylori positive patients with peptic ulcer were randomly assigned to one of two regimens: (i) triple therapy with amoxicillin, clarithromycin and lansoprazole twice daily for 2 weeks or (ii) dual therapy with amoxicillin and lansoprazole three times daily for 2 weeks. The success of eradication was evaluated 4 to 5 weeks after completing treatment.

RESULTS:

The eradication rate was 82.8% in the triple therapy group and 78.4% in the dual therapy group by per protocol analysis. This difference was not significant (P= 0.573). Adverse events were more frequent in the triple therapy group than in the dual therapy group (P= 0.002).

CONCLUSIONS:

Because dual therapy had fewer side effects than triple therapy and a similar eradication rate, dual therapy may provide an acceptable alternative first line therapy for H. pylori eradication in Korea.

• Authors: Seung Young Kim, Sung Woo Jung, Jeong Han Kim, Ja Seol Koo, Hyung Joon Yim, Jong Jae Park, Hoon Jai Chun, Sang Woo Lee, Jai Hyun Choi
• Journal: British journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 73 Issue 1 Pg. 140-3 (Jan 2012) ISSN: 1365-2125 [Electronic] England
• PMID: 21689141 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © 2011 The Authors. British Journal of Clinical Pharmacology © 2011 The British Pharmacological Society.

Chemical References

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Anti-Bacterial Agents
• Enzyme Inhibitors
• Proton Pump Inhibitors
• Lansoprazole
• Amoxicillin
• Clarithromycin

Topics

• 2-Pyridinylmethylsulfinylbenzimidazoles (administration & dosage, adverse effects)
• Adult
• Amoxicillin (administration & dosage, adverse effects)
• Anti-Bacterial Agents (administration & dosage, adverse effects)
• Clarithromycin (administration & dosage, adverse effects)
• Drug Administration Schedule
• Drug Therapy, Combination
• Enzyme Inhibitors (administration & dosage, adverse effects)
• Female
• Helicobacter Infections (drug therapy)
• Helicobacter pylori (drug effects)
• Humans
• Lansoprazole
• Male
• Middle Aged
• Proton Pump Inhibitors
• Republic of Korea
• Treatment Outcome