Abstract | BACKGROUND: OBJECTIVE: METHODS: RESULTS:
Leptin levels were significantly higher in patients with SLE than in controls (23.7±28.0 vs 13.3±12.9 ng/ml, p<0.001). Leptin was also higher in the 43 patients with SLE with plaque than without plaque (36.4±32.3 vs 20.9±26.4 ng/ml, p=0.002). After multivariate analysis, the only significant factors associated with plaque in SLE were leptin levels in the highest quartile (≥29.5 ng/ml) (OR=2.8, p=0.03), proinflammatory HDL (piHDL) (OR=12.8, p<0.001), age (OR=1.1, p<0.001), tobacco use (OR=7.7, p=0.03) and hypertension (OR=3.0, p=0.01). Adiponectin levels were not significantly associated with plaque in our cohort. A significant correlation between leptin and piHDL function (p<0.001), Lp(a) (p=0.01) and OxPL/apoB100 (p=0.02) was also present. CONCLUSIONS:
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Authors | Maureen McMahon, Brian J Skaggs, Lori Sahakian, Jennifer Grossman, John FitzGerald, Nagesh Ragavendra, Christina Charles-Schoeman, Marissa Chernishof, Alan Gorn, Joseph L Witztum, Weng Kee Wong, Michael Weisman, Daniel J Wallace, Antonio La Cava, Bevra H Hahn |
Journal | Annals of the rheumatic diseases
(Ann Rheum Dis)
Vol. 70
Issue 9
Pg. 1619-24
(Sep 2011)
ISSN: 1468-2060 [Electronic] England |
PMID | 21670088
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adipokines
- Biomarkers
- Inflammation Mediators
- Leptin
- Lipids
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Topics |
- Adipokines
(blood)
- Adult
- Atherosclerosis
(blood, diagnostic imaging, etiology)
- Biomarkers
(blood)
- Body Mass Index
- Carotid Artery, Common
(diagnostic imaging)
- Epidemiologic Methods
- Female
- Humans
- Inflammation Mediators
(blood)
- Leptin
(blood)
- Lipids
(blood)
- Lupus Erythematosus, Systemic
(blood, complications)
- Middle Aged
- Oxidation-Reduction
- Ultrasonography
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