Abstract | OBJECTIVE: To measure the changes in whole blood fatty acid levels in premature infants and evaluate associations between these changes and neonatal morbidities. STUDY DESIGN: This was a retrospective cohort study of 88 infants born at <30 weeks' gestation. Serial fatty acid profiles during the first postnatal month and infant outcomes, including chronic lung disease (CLD), retinopathy of prematurity, and late-onset sepsis, were analyzed. Regression modeling was applied to determine the association between fatty acid levels and neonatal morbidities. RESULTS:
Docosahexaenoic acid (DHA) and arachidonic acid levels declined rapidly in the first postnatal week, with a concomitant increase in linoleic acid levels. Decreased DHA level was associated with an increased risk of CLD (OR, 2.5; 95% CI, 1.3-5.0). Decreased arachidonic acid level was associated with an increased risk of late-onset sepsis (hazard ratio, 1.4; 95% CI, 1.1-1.7). The balance of fatty acids was also a predictor of CLD and late-onset sepsis. An increased linoleic acid:DHA ratio was associated with an increased risk of CLD (OR, 8.6; 95% CI, 1.4-53.1) and late-onset sepsis (hazard ratio, 4.6; 95% CI, 1.5-14.1). CONCLUSION: Altered postnatal fatty acid levels in premature infants are associated with an increased risk of CLD and late-onset sepsis.
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Authors | Camilia R Martin, Deborah A Dasilva, Joanne E Cluette-Brown, Clementina Dimonda, Ashley Hamill, Abdul Q Bhutta, Emmanuel Coronel, Michael Wilschanski, Alisa J Stephens, David F Driscoll, Bruce R Bistrian, James H Ware, Munir M Zaman, Steven D Freedman |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 159
Issue 5
Pg. 743-749.e1-2
(Nov 2011)
ISSN: 1097-6833 [Electronic] United States |
PMID | 21658712
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Mosby, Inc. All rights reserved. |
Chemical References |
- Fatty Acids
- Docosahexaenoic Acids
- Arachidonic Acid
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Topics |
- Arachidonic Acid
(blood)
- Chronic Disease
- Cohort Studies
- Docosahexaenoic Acids
(blood)
- Fatty Acids
(blood)
- Female
- Humans
- Infant, Newborn
- Infant, Premature
(blood)
- Lung Diseases
(blood, epidemiology)
- Male
- Oxygen Inhalation Therapy
- Proportional Hazards Models
- Retinopathy of Prematurity
(blood, epidemiology)
- Retrospective Studies
- Sepsis
(blood, epidemiology)
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