Abstract | INTRODUCTION: AREAS COVERED: Based on recent progress in terms of etiology and pathogenesis of TTP, several innovative therapies have been proposed in the last few years. This review provides an overview of results obtained with the ?new? therapeutic options in the light of the ?old? treatments that have been already validated by clinical trials. EXPERT OPINION:
Plasma exchange and steroids are still the most effective treatments for TTP, but several new therapeutic approaches promise to further improve the prognosis of affected patients. Immunosuppressants stronger than steroids are expected to inhibit the production of anti-ADAMTS13 autoantibodies in acquired forms when the standard approach fails to reach this goal. Moreover, new antithrombotic drugs are expected to reduce the risk of thrombosis during the period required for inhibiting the production of autoantibodies. Finally, the possibility of replacing the infusion of fresh frozen plasma with recombinant ADAMTS13 could further improve the prognosis of TTP, especially in subjects with familial forms.
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Authors | Patrizia Noris, Carlo L Balduini |
Journal | Expert opinion on investigational drugs
(Expert Opin Investig Drugs)
Vol. 20
Issue 8
Pg. 1087-98
(Aug 2011)
ISSN: 1744-7658 [Electronic] England |
PMID | 21657946
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Animals
- Clinical Trials as Topic
- Drugs, Investigational
(pharmacology, therapeutic use)
- Humans
- Prognosis
- Purpura, Thrombotic Thrombocytopenic
(drug therapy, therapy)
- Treatment Outcome
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