Isolation of chemical constituents from the aerial parts of Verbascum thapsus and their antiangiogenic and antiproliferative activities.

Abstract

Phytochemical investigation of Verbascum thapsus led to the isolation and identification of one new iridoid compound named verbathasin A, along with ten known compounds. The structure and relative stereochemistry of verbathasin A were elucidated by analysis of spectroscopic data. All the isolates except 10-deoxyeucommiol and ajugol were tested for antiangiogenic and antiproliferative activities, and compounds luteolin and 3-O-fucopyranosylsaikogenin F showed promising antiproliferative activities, with an obvious effect of inducing apoptosis of A549 lung cancer cells.

• Authors: Yan-Li Zhao, Si-Feng Wang, Yang Li, Qiu-Xia He, Ke-Chun Liu, Yong-Ping Yang, Xiao-Li Li
• Journal: Archives of pharmacal research (Arch Pharm Res) Vol. 34 Issue 5 Pg. 703-7 (May 2011) ISSN: 1976-3786 [Electronic] Korea (South)
• PMID: 21656353 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 3-O-fucopyranosylsaikogenin F
• Angiogenesis Inhibitors
• Antineoplastic Agents, Phytogenic
• Drugs, Chinese Herbal
• Glycosides
• Iridoids
• Sapogenins
• Saponins
• Luteolin

Topics

• Angiogenesis Inhibitors (chemistry, isolation & purification, pharmacology)
• Animals
• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Apoptosis (drug effects)
• Blood Vessels (drug effects)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Drugs, Chinese Herbal (chemistry)
• Embryo, Nonmammalian (drug effects)
• Ethnopharmacology
• Glycosides (chemistry, isolation & purification, pharmacology)
• Humans
• Iridoids (chemistry, isolation & purification, pharmacology)
• Lung Neoplasms (drug therapy, pathology)
• Luteolin (chemistry, isolation & purification, pharmacology)
• Molecular Structure
• Plant Components, Aerial (chemistry)
• Sapogenins (chemistry, isolation & purification, pharmacology)
• Saponins (chemistry, isolation & purification, pharmacology)
• Stereoisomerism
• Verbascum (chemistry)
• Zebrafish