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harpagide

from S. African plant Harpagophytum procumbens DC

Also Known As:

ajugol; leonuride; myoporoside

Networked: 15 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gxaba, Nomagugu: 1 article (06/2022)
2.	Manganyi, Madira Coutlyne: 1 article (06/2022)
3.	Atolani, Olubunmi: 1 article (01/2022)
4.	Ebhuoma, Osadolor O: 1 article (01/2022)
5.	Erukainure, Ochuko L: 1 article (01/2022)
6.	Ibeji, Collins U: 1 article (01/2022)
7.	Katsayal, Sanusi B: 1 article (01/2022)
8.	Mesaik, M Ahmed: 1 article (01/2022)
9.	Muhammad, Aliyu: 1 article (01/2022)
10.	Guan, Lingling: 1 article (12/2021)

Related Diseases

1.	Inflammation (Inflammations) 10/01/2022 - "Here we aimed to investigated whether leonuride provided a therapeutic efficacy in reversing asthma airway remodeling and inflammation and uncover the underlying mechanisms. " 10/01/2022 - "Leonuride suppressed airway inflammation evidenced by the significant reductions in accumulation of inflammatory cells around bronchi and vessels, leukocyte population counts and the abundance of type 2 inflammatory mediators (OVA specific IgE, IL-4, IL-5 and IL-13) in bronchoalveolar lavage fluid (BALF). " 05/01/2008 - "Its major active components, harpagoside (1), harpagide (2), 8-coumaroylharpagide (3), and verbascoside (4), are believed to interact either synergistically or antagonistically in modulating the enzymes responsible for inducing inflammation, although this has not been probed hitherto. " 10/01/2022 - "A novel iridoid glycoside leonuride (ajugol) attenuates airway inflammation and remodeling through inhibiting type-2 high cytokine/chemokine activity in OVA-induced asthmatic mice."
2.	Airway Remodeling 10/01/2022 - "Here we aimed to investigated whether leonuride provided a therapeutic efficacy in reversing asthma airway remodeling and inflammation and uncover the underlying mechanisms. "
3.	Brain Injuries (Brain Injury) 05/10/2020 - "Harpagide has shown promise in the treatment of oxygen-glucose deprivation and reoxygenation (OGD/R)-induced brain injury. "
4.	Asthma (Bronchial Asthma) 10/01/2022 - "However, no pharmacological effects of leonuride in asthma were reported. " 10/01/2022 - "Here we aimed to investigated whether leonuride provided a therapeutic efficacy in reversing asthma airway remodeling and inflammation and uncover the underlying mechanisms. " 10/01/2022 - "Our results revealed the therapeutic efficacy of leonuride in experimental chronic asthma for the first time, and implied that its anti-inflammatory and antifibrotic properties might be mediated by regulation of type-2 high cytokine/chemokines responses."
5.	Pain (Aches) 06/06/2022 - "Harpagoside and harpagide, iridoid glycosides bioactive compounds have been reported in countless phytochemical studies as potential anti-inflammatory agents as well as pain relievers. "

Related Drugs and Biologics

1.	Chemokines
2.	Cytokines
3.	Oxygen (Dioxygen)
4.	Glucose (Dextrose)
5.	harpagoside
6.	Phytochemicals
7.	Iridoid Glycosides
8.	Anti-Inflammatory Agents (Anti-Inflammatories)
9.	aucubin
10.	Chlorogenic Acid

Related Therapies and Procedures

1.	Therapeutics
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Oral Administration