Association between polymorphisms of CYP2J2 and EPHX2 genes and risk of coronary artery disease.

Abstract

OBJECTIVE:

Common polymorphisms within cytochrome P450 2J2 (CYP2J2) and epoxide hydrolase 2 (EPHX2), which are involved in the generation or hydrolysis of epoxyeicosatrienoic acids, may determine susceptibility to the development of cardiovascular disease. To derive a more precise estimation of their relationship, we undertook a case-control study as well as a meta-analysis to assess possible associations of coronary artery disease (CAD) risk with CYP2J2 and EPHX2 genetic variations.

METHODS:

Associations among four single nucleotide polymorphisms in CYP2J2 and five in EPHX2 with CAD were examined in a total of 1344 cases and 1267 ethnically and geographically matched controls. To further confirm the effect of two functional variants (G-50T and R287Q) in the development of CAD, we conducted a meta-analysis including seven studies on G-50T polymorphism and six studies on R287Q polymorphism before June 2010.

RESULTS:

No significant association between common polymorphisms within these two genes and CAD was observed in our sample, either using methods of single-locus analysis or haplotype-based analysis. In addition, no association was detected in our meta-analysis between these two functional variants and the risk of developing CAD.

CONCLUSION:

This case-control study as well as meta-analysis suggested no association between CYP2J2 G-50T and EPHX2 R287Q and the risk of developing CAD.

• Authors: Yujun Xu, Hu Ding, Jia Peng, Guanglin Cui, Lei Liu, Katherine Cianflone, Dao Wen Wang
• Journal: Pharmacogenetics and genomics (Pharmacogenet Genomics) Vol. 21 Issue 8 Pg. 489-94 (Aug 2011) ISSN: 1744-6880 [Electronic] United States
• PMID: 21642892 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• CYP2J2 protein, human
• Cytochrome P-450 Enzyme System
• Cytochrome P-450 CYP2J2
• Epoxide Hydrolases
• EPHX2 protein, human

Topics

• Aged
• Case-Control Studies
• Coronary Artery Disease (genetics)
• Cytochrome P-450 CYP2J2
• Cytochrome P-450 Enzyme System (genetics)
• Epoxide Hydrolases (genetics)
• Female
• Genetic Association Studies
• Genetic Predisposition to Disease
• Haplotypes
• Humans
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Risk Factors