Association of IL-12p40 +1188 A/C polymorphism with nasopharyngeal cancer risk and tumor extension.

Abstract

The interleukin 12 (IL-12) cytokine, encoded by polymorphic genes, plays a central role in the T helper 1 cell-mediated immunity against tumors. We investigated whether the 3' untranslated region +1188 A/C polymorphism (rs 3212227) influences the nasopharyngeal carcinoma (NPC) risk in Tunisian patients. DNA analysis of 247 patients and 284 healthy individuals showed a higher frequency of the 1188 C allele and the CC genotype in patients than in controls (P = 0.00001 and P = 0.00005) suggesting that the C variant allele is associated with the susceptibility to NPC. Additional testing showed that the homozygous CC genotype is also associated with advanced stage of the tumor extension at presentation (P = 0.022). Our data suggest that the impaired production of IL-12 behaves as a risk factor for NPC occurrence and progression.

• Authors: A Ben Chaaben, M Busson, H Douik, W Boukouaci, T Mamoghli, L Chaouch, L Harzallah, S Dorra, C Fortier, A Ghanem, D Charron, R Krishnamoorthy, F Guemira, R Tamouza
• Journal: Tissue antigens (Tissue Antigens) Vol. 78 Issue 2 Pg. 148-51 (Aug 2011) ISSN: 1399-0039 [Electronic] England
• PMID: 21623733 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2011 John Wiley & Sons A/S.

Chemical References

• Interleukin-12 Subunit p40

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Child
• Female
• Genetic Predisposition to Disease
• Genotype
• Humans
• Interleukin-12 Subunit p40 (genetics)
• Male
• Middle Aged
• Models, Statistical
• Nasopharyngeal Neoplasms (genetics)
• Neoplasm Metastasis
• Polymorphism, Genetic
• Retrospective Studies
• Risk
• Sequence Analysis, DNA
• Tunisia