Correlation between improvement in functional signs and plethysmographic parameters during venoactive treatment (Cyclo 3 Fort).

Abstract

AIM:

The aim of this study was to compare the change in functional signs of venous insufficiency and venous refilling time measured by mercury strain-gauge plethysmography under the effects of the combination of Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid (Cyclo 3 Fort).

METHODS:

An open-label clinical trial conducted in 65 women presenting with CEAP class C2s and C3s assessment criteria. At D0 and D28, functional signs were measured on a visual analog scale (VAS), venous refilling time by mercury strain-gauge plethysmography and venous reflux by echo-Doppler method.

RESULTS:

Under treatment, venous refilling time increased from 11.7±4 s to 13.8±4.4 s with Δ of 26% (P<0.0001) and the percentage of patients showing improvement of functional symptoms ≥30% was significantly correlated (P=0.04) with the percentage of patients presenting an improvement in venous refilling time ≥10%.

CONCLUSION:

Improvement in subjective functional signs under treatment with Cyclo 3 Fort was correlated with objective plethysmographic parameter improvement. There-fore, this study contributes to objectively document the benefit of prescribing this venoactive drug to active women with CEAP class C2s to C3s.

• Authors: F A Allaert, C Hugue, M Cazaubon, J M Renaudin, T Clavel, P Escourrou
• Journal: International angiology : a journal of the International Union of Angiology (Int Angiol) Vol. 30 Issue 3 Pg. 272-7 (Jun 2011) ISSN: 1827-1839 [Electronic] Italy
• PMID: 21617611 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Cardiovascular Agents
• Chalcones
• Plant Extracts
• cyclo 3
• hesperidin methylchalcone
• Hesperidin
• Ascorbic Acid

Topics

• Activities of Daily Living
• Analysis of Variance
• Ascorbic Acid (therapeutic use)
• Cardiovascular Agents (therapeutic use)
• Chalcones (therapeutic use)
• Chi-Square Distribution
• Drug Therapy, Combination
• Female
• France
• Hesperidin (analogs & derivatives, therapeutic use)
• Humans
• Plant Extracts (therapeutic use)
• Plethysmography
• Predictive Value of Tests
• Recovery of Function
• Ruscus
• Treatment Outcome
• Ultrasonography, Doppler
• Venous Insufficiency (diagnosis, drug therapy, physiopathology)