Glycated hemoglobin, diabetes mellitus, and cardiovascular risk in a cross-sectional study among She Chinese population.

Abstract

OBJECTIVE:

To determine whether glycated hemoglobin (HbA1c) could be used to diagnose Type 2 diabetes mellitus in She Chinese People and to assess the role of HbA1c in the development of cardiovascular disease.

RESEARCH DESIGN AND METHODS:

An ethnically representative sample of 687 (277 males and 410 females) adults, 20 yr of age or older participated in the study, and 75-g oral glucose tolerance test was administrated. Based on receiver operating characteristic curves, various cut-off values of HbA1c were used to stratify glucose tolerance. Several indexes were used to assess the cardiovascular risk, including estimated glomerular filtration rate (eGFR), Tpeak-end, Tp-e dispersion, aVL R wave, and QTc.

RESULTS:

Using World Health Organization as gold standard, the HbA1c value of 6.9% was optimal to diagnose diabetes mellitus with a sensitivity of 35.3% and specificity of 94.0%. And for impaired fasting glucose, impaired glucose tolerance, and impaired glucose regulation, the cut-off points were all 6.1%. Assessed by logistic regression model, HbA1c was an independent risk factor for the decline in eGFR; R wave in lead aVL increased significantly (p<0.05) with the increase of HbA1c values. Other indexes reflecting the cardiovascular risks were not meaningful in our study.

CONCLUSIONS:

HbA1c may be not a preferred method to diagnose Type2 diabetes in She Chinese people. However, more attention should be paid to subjects with HbA1c>6.1%, and their blood glucose should be tightly measured in clinical practice. In addition, we suggest that HbA1c is a predictor of cardiovascular disease.

• Authors: Y Lin, Y Xu, G Chen, B Huang, Z Chen, L Yao, Z Chen
• Journal: Journal of endocrinological investigation (J Endocrinol Invest) Vol. 35 Issue 1 Pg. 35-41 (Jan 2012) ISSN: 1720-8386 [Electronic] Italy
• PMID: 21613810 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Glycated Hemoglobin A

Topics

• Adult
• Aged
• Asian People
• Blood Glucose (analysis)
• Cardiovascular Diseases (diagnosis, epidemiology, etiology)
• China (epidemiology)
• Cross-Sectional Studies
• Diabetes Complications (diagnosis, epidemiology, etiology)
• Diabetes Mellitus, Type 2 (blood, diagnosis)
• Fasting
• Female
• Glucose Tolerance Test
• Glycated Hemoglobin
• Humans
• Male
• Middle Aged
• Prediabetic State
• ROC Curve
• Risk Factors
• Young Adult